HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: TRI69 (Q86WT6)
E3 ubiquitin-protein ligase TRIM69 (EC 2.3.2.27) (RFP-like domain-containing protein trimless) (RING finger protein 36) (RING-type E3 ubiquitin transferase TRIM69) (Tripartite motif-containing protein 69)
Gene: TRIM69

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016607 - nuclear speck
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 664 Hs			1 500
+	Hs
		531606 K2C5_HUMAN (24-390): 2.24e-117: 364: 25.95		TRI58_HUMAN (26-498): 5.26e-131: 390: 26.51
+	Hs
		821686 K2C6C_HUMAN (24-407): 2.49e-116: 361: 24.03		TRIM7_HUMAN (36-498): 8.99e-116: 352: 28.46
+	Hs
		360442 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		TRI39_HUMAN (32-499): 6.3e-143: 422: 30.62
+	Hs
		359651 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		RO52_HUMAN (26-498): 1.18e-141: 417: 28.39
+	Hs
		360383 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		TRIM6_HUMAN (27-499): 1.47e-113: 346: 27.62
+	Hs
		584872 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		RO52_HUMAN (26-498): 1.18e-141: 417: 28.39
+	Hs
		62675 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		TRI64_HUMAN (32-483): 1.35e-110: 337: 22.76
+	Hs
		536792 LMNB2_HUMAN (21-580): 7.45e-51: 188: 52.68		TRI27_HUMAN (26-498): 1.05e-131: 393: 27.68
+	Hs
		318774 K2C75_HUMAN (23-390): 1.2e-45: 172: 23.85		TRI27_HUMAN (26-498): 1.05e-131: 393: 27.68
+	Hs
		535455 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		TRI69_HUMAN (1-500): 1.48e-146: 430: 100.00
+	Hs
		443320 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		RO52_HUMAN (26-498): 1.18e-141: 417: 28.39
+	Hs
		443583 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		TRI68_HUMAN (26-497): 1.81e-130: 389: 28.05
+	Hs
		535315 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		TRI27_HUMAN (26-498): 1.05e-131: 393: 27.68
+	Hs
		443767 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		TRI62_HUMAN (34-496): 2.54e-116: 352: 30.44
+	Hs
		443785 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		TRI15_HUMAN (26-487): 3.87e-99: 308: 25.84
+	Hs
		380469 K2C6B_HUMAN (24-407): 5.03e-115: 357: 23.51		TRI26_HUMAN (392-480): 1.97e-12: 71.2: 43.82
+	Hs
		360212 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		BT2A2_HUMAN (325-480): 5.37e-38: 147: 48.10
+	Hs
		359894 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		TRI26_HUMAN (392-480): 1.97e-12: 71.2: 43.82