HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: RN138 (Q8WVD3)
E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138)
Gene: RNF138

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0035861 - site of double-strand break
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 664 Hs			1 245
+	Hs
		531648 K2C5_HUMAN (24-390): 2.24e-117: 364: 25.95		TRAF6_HUMAN (12-245): 1.55e-33: 128: 16.25
+	Hs
		380469 K2C6B_HUMAN (24-407): 5.03e-115: 357: 23.51		TRI26_HUMAN (4-239): 2.73e-33: 127: 15.64
+	Hs
		280824 KRT36_HUMAN (31-457): 9.65e-119: 364: 23.83		TRAF4_HUMAN (8-207): 1.85e-27: 111: 13.14
+	Hs
		821686 K2C6C_HUMAN (24-407): 2.49e-116: 361: 24.03		TRIM7_HUMAN (13-181): 8.22e-28: 112: 14.51
+	Hs
		531626 K2C5_HUMAN (24-390): 2.24e-117: 364: 25.95		TRI31_HUMAN (6-156): 1.18e-25: 105: 17.65
+	Hs
		359894 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		TRI26_HUMAN (4-239): 2.73e-33: 127: 15.64
+	Hs
		62675 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		TRI64_HUMAN (6-239): 9.89e-33: 125: 14.41
+	Hs
		359651 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		RO52_HUMAN (6-157): 6.92e-32: 123: 17.11
+	Hs
		360442 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		TRI39_HUMAN (9-186): 1.44e-28: 114: 17.22
+	Hs
		360383 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		TRIM6_HUMAN (5-182): 3.29e-27: 110: 15.76
+	Mm
		839467 K2C6A_MOUSE (23-390): 8.31e-40: 155: 23.58		RN138_MOUSE (1-245): 1.2e-56: 182: 93.88
+	Hs
		584872 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		RO52_HUMAN (6-157): 6.92e-32: 123: 17.11
+	Hs
		975721 LMNB2_HUMAN (21-580): 7.45e-51: 188: 52.68		RING2_HUMAN (2-188): 8.11e-29: 112: 18.72
+	Mm
		69787 KRT36_MOUSE (30-387): 3.9e-49: 180: 24.02		TRAF3_MOUSE (2-245): 1.13e-28: 115: 14.69
+	Mm
		1141443 KRT81_MOUSE (25-387): 1.63e-47: 176: 24.38		TRAF3_MOUSE (2-245): 1.13e-28: 115: 14.69
+	Mm
		1141414 KRT87_MOUSE (25-387): 4.84e-47: 175: 24.11		TRAF3_MOUSE (2-245): 1.13e-28: 115: 14.69
+	Hs
		595395 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		TRI31_HUMAN (6-156): 1.18e-25: 105: 17.65
+	Mm
		957023 KRT86_MOUSE (25-387): 1.24e-46: 173: 24.38		TRAF3_MOUSE (2-245): 1.13e-28: 115: 14.69
+	Hs
		443320 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		RO52_HUMAN (6-157): 6.92e-32: 123: 17.11
+	Hs
		443583 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		TRI68_HUMAN (4-235): 8.64e-29: 115: 14.94