HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: RAD50 (Q92878)
DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-)
Gene: RAD50

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	29568061, unassigned1655
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035861 - site of double-strand break
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 664 Hs			1 1312
+	Hs
		531529 K2C5_HUMAN (24-390): 2.24e-117: 364: 25.95		DESP_HUMAN (190-1069): 1.96e-10: 67.8: 18.71
+	Hs
		359462 K2C6A_HUMAN (23-407): 5.26e-116: 360: 23.71		DESP_HUMAN (190-1069): 1.96e-10: 67.8: 18.71
+	Mm
		821725 LMNA_MOUSE (1-664): 1.23e-70: 243: 94.90		MYH9_MOUSE (602-1198): 2.62e-23: 110: 8.58
+	Hs
		148260 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		CTRO_HUMAN (732-1116): 8.66e-10: 65.7: 12.15
+	Hs
		359578 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		LAMB1_HUMAN (457-960): 2.73e-09: 63.9: 18.88
+	Dm
		115255 LAM0_DROME (13-582): 4.03e-44: 169: 34.59		M9PEK6_DROME (223-1121): 8.26e-33: 141: 15.53
+	Hs
		148705 LMNB2_HUMAN (21-580): 7.45e-51: 188: 52.68		CTRO_HUMAN (732-1116): 8.66e-10: 65.7: 12.15
+	Hs
		148391 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		CTRO_HUMAN (732-1116): 8.66e-10: 65.7: 12.15
+	Hs
		443305 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		DESP_HUMAN (190-1069): 1.96e-10: 67.8: 18.71
+	Hs
		148307 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		CTRO_HUMAN (732-1116): 8.66e-10: 65.7: 12.15
+	Hs
		535318 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		DESP_HUMAN (190-1069): 1.96e-10: 67.8: 18.71
+	Mm
		93542 NFL_MOUSE (28-411): 3.76e-26: 115: 29.64		DESP_MOUSE (190-1069): 1.15e-11: 72: 18.72
+	Hs
		551603 DESM_HUMAN (27-389): 6.1e-28: 119: 30.03		DESP_HUMAN (190-1069): 1.96e-10: 67.8: 18.71
+	Hs
		148347 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		CTRO_HUMAN (732-1116): 8.66e-10: 65.7: 12.15
+	Hs
		148372 DESM_HUMAN (27-389): 6.1e-28: 119: 30.03		CTRO_HUMAN (732-1116): 8.66e-10: 65.7: 12.15
+	Hs
		148291 NFL_HUMAN (28-433): 1.96e-26: 115: 27.07		CTRO_HUMAN (732-1116): 8.66e-10: 65.7: 12.15