HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: P121A (Q96HA1)
Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa)
Gene: POM121

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.702

Property	Details
Experiments	24927568, 29568061, 34079125, 32344865, 22412018
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005635 - nuclear envelope GO:0005654 - nucleoplasm GO:0006606 - protein import into nucleus GO:0031965 - nuclear membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 664 Hs			1 1249
+	Hs
		595357 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		P121A_HUMAN (1-1249): 2.73e-82: 296: 100.00
+	Hs
		535527 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		P121A_HUMAN (1-1249): 2.73e-82: 296: 100.00
+	Hs
		359790 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		NUP98_HUMAN (828-1223): 9.68e-19: 95.1: 19.77
+	Hs
		359712 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		NU214_HUMAN (91-1211): 3.61e-15: 83.5: 12.90
+	Hs
		359942 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		MDC1_HUMAN (87-1249): 8.98e-14: 78.8: 9.17
+	Hs
		72703 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		B4DET5_HUMAN (79-778): 1.43e-13: 77.5: 11.14
+	Hs
		360312 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		CIC_HUMAN (128-1161): 2.11e-09: 64.5: 9.81
+	Ce
		106859 IFA4_CAEEL (5-548): 5.76e-69: 237: 25.18		NUP98_CAEEL (820-1233): 7.01e-18: 92.1: 17.23
+	Hs
		360546 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		SRRM2_HUMAN (3-891): 8.36e-09: 62.5: 10.62
+	Ce
		106862 LMN1_CAEEL (1-539): 1.07e-53: 195: 29.49		NUP98_CAEEL (820-1233): 7.01e-18: 92.1: 17.23
+	Dr
		71416 B3DKC5_DANRE (9-597): 8e-53: 194: 65.08		E7F981_DANRE (826-1239): 3.19e-16: 86.7: 21.05
+	Hs
		595161 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		NUP98_HUMAN (828-1223): 9.68e-19: 95.1: 19.77
+	Dr
		71444 B3DKC5_DANRE (9-597): 8e-53: 194: 65.08		F1R543_DANRE (2-784): 8.38e-13: 75.3: 10.72
+	Hs
		975718 LMNB2_HUMAN (21-580): 7.45e-51: 188: 52.68		CIC_HUMAN (128-1161): 2.11e-09: 64.5: 9.81
+	Hs
		1205250 K2C73_HUMAN (23-390): 1.74e-50: 185: 23.85		CIC_HUMAN (128-1161): 2.11e-09: 64.5: 9.81
+	Hs
		595369 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		CIC_HUMAN (128-1161): 2.11e-09: 64.5: 9.81
+	Hs
		595471 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		SRRM2_HUMAN (3-891): 8.36e-09: 62.5: 10.62
+	Hs
		443743 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		CIC_HUMAN (128-1161): 2.11e-09: 64.5: 9.81
+	Hs
		443883 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		SRRM2_HUMAN (3-891): 8.36e-09: 62.5: 10.62