HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: SMUF1 (Q9HCE7)
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Gene: SMURF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	20804422
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 664 Hs			1 757
+	Hs
		280825 KRT36_HUMAN (31-457): 9.65e-119: 364: 23.83		SMUF1_HUMAN (1-757): 0: 891: 100.00
+	Hs
		360429 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		SMUF2_HUMAN (1-757): 0: 794: 70.72
+	Hs
		443826 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		SMUF1_HUMAN (1-757): 0: 891: 100.00
+	Hs
		569126 DESM_HUMAN (27-389): 6.1e-28: 119: 30.03		SMUF2_HUMAN (1-757): 0: 794: 70.72
+	Hs
		360500 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		HECW2_HUMAN (1-322): 1.89e-15: 82.9: 14.87
+	Hs
		595456 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		HECW2_HUMAN (1-322): 1.89e-15: 82.9: 14.87