HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: CHD8 (Q9HCK8)
Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.12) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1)
Gene: CHD8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22412018
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 664 Hs			1 2581
+	Hs
		531559 K2C5_HUMAN (24-390): 2.24e-117: 364: 25.95		CHD3_HUMAN (385-2065): 0: 1037: 23.37
+	Hs
		821652 K2C6C_HUMAN (24-407): 2.49e-116: 361: 24.03		CHD3_HUMAN (385-2065): 0: 1037: 23.37
+	Hs
		359486 K2C6A_HUMAN (23-407): 5.26e-116: 360: 23.71		CHD3_HUMAN (385-2065): 0: 1037: 23.37
+	Hs
		380468 K2C6B_HUMAN (24-407): 5.03e-115: 357: 23.51		CHD3_HUMAN (385-2065): 0: 1037: 23.37
+	Hs
		531571 K2C5_HUMAN (24-390): 2.24e-117: 364: 25.95		CHD4_HUMAN (500-2065): 0: 981: 23.88
+	Hs
		821658 K2C6C_HUMAN (24-407): 2.49e-116: 361: 24.03		CHD4_HUMAN (500-2065): 0: 981: 23.88
+	Hs
		359491 K2C6A_HUMAN (23-407): 5.26e-116: 360: 23.71		CHD4_HUMAN (500-2065): 0: 981: 23.88
+	Hs
		380476 K2C6B_HUMAN (24-407): 5.03e-115: 357: 23.51		CHD4_HUMAN (500-2065): 0: 981: 23.88
+	Hs
		359892 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		CHD3_HUMAN (385-2065): 0: 1037: 23.37
+	Dr
		71460 B3DKC5_DANRE (9-597): 8e-53: 194: 65.08		Q1LYP4_DANRE (360-2065): 0: 1059: 22.92
+	Hs
		595204 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		CHD3_HUMAN (385-2065): 0: 1037: 23.37
+	Hs
		1059714 K2C73_HUMAN (23-390): 1.74e-50: 185: 23.85		CHD4_HUMAN (500-2065): 0: 981: 23.88
+	Hs
		443482 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		CHD3_HUMAN (385-2065): 0: 1037: 23.37
+	Hs
		595230 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		CHD4_HUMAN (500-2065): 0: 981: 23.88
+	Hs
		422170 NFL_HUMAN (28-433): 1.96e-26: 115: 27.07		CHD3_HUMAN (385-2065): 0: 1037: 23.37
+	Hs
		229272 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		SMCA5_HUMAN (687-1722): 0: 886: 26.82
+	Hs
		1055184 K1H2_HUMAN (30-387): 6.02e-43: 162: 23.18		CHD4_HUMAN (500-2065): 0: 981: 23.88
+	Hs
		443520 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		CHD4_HUMAN (500-2065): 0: 981: 23.88
+	Dr
		71538 B3DKC5_DANRE (9-597): 8e-53: 194: 65.08		Q7ZSY3_DANRE (75-1462): 0: 795: 22.95
+	Hs
		535355 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		SMCA2_HUMAN (101-1489): 0: 797: 22.14