HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: TNPO3 (Q9Y5L0)
Transportin-3 (Importin-12) (Imp12) (Transportin-SR) (TRN-SR)
Gene: TNPO3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	32344865
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005635 - nuclear envelope GO:0006606 - protein import into nucleus
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 664 Hs			1 923
+	Hs
		595489 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		TNPO3_HUMAN (1-923): 0: 657: 100.00
+	Hs
		318909 K2C75_HUMAN (23-390): 1.2e-45: 172: 23.85		TNPO3_HUMAN (1-923): 0: 657: 100.00
+	Hs
		162403 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		XPO1_HUMAN (3-920): 6.76e-151: 475: 12.37
+	Hs
		297182 K2C73_HUMAN (23-390): 1.74e-50: 185: 23.85		IPO13_HUMAN (5-923): 2.1e-143: 452: 21.02
+	Hs
		162349 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		XPO1_HUMAN (3-920): 6.76e-151: 475: 12.37
+	Xl
		624256 VIM1_XENLA (25-418): 2.66e-30: 126: 26.01		Q6NS03_XENLA (3-918): 4.57e-148: 467: 12.80
+	Xl
		1155703 Q7ZXU4_XENLA (28-387): 2.91e-26: 115: 27.75		Q6NS03_XENLA (3-918): 4.57e-148: 467: 12.80
+	Mm
		821718 LMNA_MOUSE (1-664): 1.23e-70: 243: 94.90		TNPO1_MOUSE (66-784): 5.88e-93: 316: 12.71
+	Hs
		207863 K2C75_HUMAN (23-390): 1.2e-45: 172: 23.85		XPOT_HUMAN (12-770): 1.76e-93: 318: 15.10
+	Hs
		155504 K2C75_HUMAN (23-390): 1.2e-45: 172: 23.85		TNPO2_HUMAN (68-784): 3.33e-92: 313: 12.26