HitPredict

Interactor 1: TNNC2 (P02585)
Troponin C, skeletal muscle
Gene: TNNC2

Interactor 2: TNNI3 (P19429)
Troponin I, cardiac muscle (Cardiac troponin I)
Gene: TNNI3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	25416956, 25910212
Identification Methods	two hybrid, two hybrid bait and prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	EF-hand_7~Troponin
Common GO terms	GO:0003009 - skeletal muscle contraction GO:0005829 - cytosol GO:0005861 - troponin complex
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 160 Hs			1 210
+	Hs
		584293 TNNC1_HUMAN (1-160): 7.64e-49: 156: 64.60		TNNI3_HUMAN (1-210): 1.43e-69: 213: 100.00
+	Hs
		361223 TNNC2_HUMAN (1-160): 2.51e-46: 149: 100.00		Q6FGX2_HUMAN (1-210): 1.43e-69: 213: 100.00
+	Gg
		455000 TNNC1_CHICK (1-160): 6.21e-49: 156: 64.60		Q6S7R6_CHICK (20-210): 1.39e-57: 182: 65.97
+	Hs
		581184 TNNC1_HUMAN (1-160): 7.64e-49: 156: 64.60		TNNI1_HUMAN (33-210): 5.72e-57: 180: 63.13
+	Hs
		822795 TNNC1_HUMAN (1-160): 7.64e-49: 156: 64.60		TNNI2_HUMAN (36-210): 2.38e-49: 160: 57.06
+	Oc
		361254 TNNC2_RABIT (1-160): 4.23e-46: 149: 99.38		TNNI2_RABIT (36-210): 1.05e-49: 161: 58.76
+	Dm
		734259 CALL_DROME (18-83): 1.02e-15: 71.3: 46.97		TNNI_DROME (3-195): 3.01e-29: 111: 27.41