HitPredict

Interactor 1: APOE (P02649)
Apolipoprotein E (Apo-E)
Gene: APOE

Interactor 2: LRP1 (Q07954)
Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]
Gene: LRP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.684

The method score is based on:

Property	Details
Experiments	2779654, 20030366, 15182176
Identification Methods	affinity chromatography technology, surface plasmon resonance, pull down, nuclear magnetic resonance, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001540 - amyloid-beta binding GO:0005634 - nucleus GO:0005769 - early endosome GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane and 8 others more... GO:0006898 - receptor-mediated endocytosis GO:0010629 - negative regulation of gene expression GO:0010875 - positive regulation of cholesterol efflux GO:0016020 - membrane GO:0043395 - heparan sulfate proteoglycan binding GO:0044877 - protein-containing complex binding GO:0045807 - positive regulation of endocytosis GO:1900223 - positive regulation of amyloid-beta clearance
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	317
Hs

1	4544

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024