HitPredict

Interactor 1: MBP (P02686)
Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein)
Gene: MBP

Interactor 2: MK01 (P28482)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: MAPK1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	0.60	0.763

Property	Details
Experiments	12588875, 22778266, 11983899, 10978313, 12944901, 10464310, 9596579, 12114318, 17906618, 14530346, 8846788, 11570821, 10958680, 10371216, 11258664, 17255944
Identification Methods	enzymatic study, affinity chromatography technology, protein kinase assay
Interaction Type	direct interaction, physical association, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007268 - chemical synaptic transmission GO:0042552 - myelination and 1 others more... GO:0045202 - synapse
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 304 Hs			1 360
+	Hs
		362059 MBP_HUMAN (1-304): 1.69e-179: 498: 100.00		MK03_HUMAN (4-358): 3.09e-154: 440: 85.92
+	Hs
		362072 MBP_HUMAN (1-304): 1.69e-179: 498: 100.00		MK12_HUMAN (1-359): 6.4e-140: 403: 40.22
+	Hs
		362091 MBP_HUMAN (1-304): 1.69e-179: 498: 100.00		MK14_HUMAN (18-356): 7.86e-112: 332: 48.97
+	Mm
		381380 MBP_MOUSE (1-240): 5.07e-132: 376: 85.06		MK01_MOUSE (10-360): 4.96e-158: 449: 99.72
+	Mm
		381388 MBP_MOUSE (1-240): 5.07e-132: 376: 85.06		MK03_MOUSE (15-357): 1.88e-152: 435: 88.63
+	Rn
		362114 MBP_RAT (134-304): 1.78e-87: 261: 81.82		MK01_RAT (10-360): 4.96e-158: 449: 99.72
+	Xl
		953599 MBP_XENLA (134-304): 1.25e-69: 215: 58.01		Q6DFK6_XENLA (2-358): 2.06e-156: 444: 95.52