HitPredict

Interactor 1: VTDB (P02774)
Vitamin D-binding protein (DBP) (VDB) (Gc protein-derived macrophage activating factor) (Gc-MAF) (GcMAF) (Gc-globulin) (Group-specific component) (Gc) (Vitamin D-binding protein-macrophage activating factor) (DBP-maf)
Gene: GC

Interactor 2: ACTA (P62736)
Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form]
Gene: ACTA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Serum_albumin, Actin~VitD-bind_III
Common GO terms	GO:0005615 - extracellular space GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 474 Hs			1 377
+	Hs
		364010 VTDB_HUMAN (1-474): 0: 556: 100.00		ACTBL_HUMAN (4-377): 0: 712: 87.97
+	Hs
		364001 VTDB_HUMAN (1-474): 0: 556: 100.00		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		364005 VTDB_HUMAN (1-474): 0: 556: 100.00		ACTS_HUMAN (1-377): 0: 598: 97.88
+	Hs
		798408 AFAM_HUMAN (10-392): 1.99e-32: 132: 20.40		ACTBL_HUMAN (4-377): 0: 712: 87.97
+	Hs
		798406 AFAM_HUMAN (10-392): 1.99e-32: 132: 20.40		ACTA_HUMAN (1-377): 0: 596: 100.00