HitPredict

Interactor 1: PLF4 (P02776)
Platelet factor 4 (PF-4) (C-X-C motif chemokine 4) (Iroplact) (Oncostatin-A) [Cleaved into: Platelet factor 4, short form (Endothelial cell growth inhibitor)]
Gene: PF4

Interactor 2: ACKR1 (Q16570)
Atypical chemokine receptor 1 (Duffy antigen/chemokine receptor) (Fy glycoprotein) (GpFy) (Glycoprotein D) (Plasmodium vivax receptor) (CD antigen CD234)
Gene: ACKR1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	8132497
Identification Methods	competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006954 - inflammatory response GO:0070098 - chemokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 101 Hs			1 336
+	Hs
		449000 GROA_HUMAN (35-101): 1.01e-27: 99: 46.27		ACKR1_HUMAN (1-336): 6.26e-100: 299: 100.00
+	Hs
		486205 IL8_HUMAN (26-100): 4.32e-25: 92: 31.58		ACKR1_HUMAN (1-336): 6.26e-100: 299: 100.00
+	Hs
		625748 CXCL5_HUMAN (21-100): 1.55e-29: 103: 41.25		CXCR2_HUMAN (14-321): 1.02e-79: 249: 21.86
+	Hs
		364042 CXCL7_HUMAN (26-99): 4.02e-28: 100: 50.00		CXCR2_HUMAN (14-321): 1.02e-79: 249: 21.86
+	Hs
		587767 CXCL2_HUMAN (30-101): 1.79e-28: 100: 41.67		CXCR2_HUMAN (14-321): 1.02e-79: 249: 21.86
+	Hs
		448988 GROA_HUMAN (35-101): 1.01e-27: 99: 46.27		CXCR2_HUMAN (14-321): 1.02e-79: 249: 21.86
+	Hs
		625758 CXCL6_HUMAN (28-101): 7.85e-27: 96.6: 40.54		CXCR2_HUMAN (14-321): 1.02e-79: 249: 21.86
+	Hs
		587786 CXCL3_HUMAN (35-100): 9.16e-27: 96.3: 40.91		CXCR2_HUMAN (14-321): 1.02e-79: 249: 21.86
+	Hs
		625736 CXCL5_HUMAN (21-100): 1.55e-29: 103: 41.25		CXCR1_HUMAN (17-321): 3.82e-77: 242: 19.64
+	Hs
		364041 CXCL7_HUMAN (26-99): 4.02e-28: 100: 50.00		CXCR1_HUMAN (17-321): 3.82e-77: 242: 19.64
+	Hs
		448987 GROA_HUMAN (35-101): 1.01e-27: 99: 46.27		CXCR1_HUMAN (17-321): 3.82e-77: 242: 19.64
+	Hs
		486185 IL8_HUMAN (26-100): 4.32e-25: 92: 31.58		CXCR2_HUMAN (14-321): 1.02e-79: 249: 21.86
+	Hs
		625737 CXCL6_HUMAN (28-101): 7.85e-27: 96.6: 40.54		CXCR1_HUMAN (17-321): 3.82e-77: 242: 19.64
+	Hs
		486184 IL8_HUMAN (26-100): 4.32e-25: 92: 31.58		CXCR1_HUMAN (17-321): 3.82e-77: 242: 19.64
+	Mm
		500672 CXCL2_MOUSE (30-100): 2.89e-28: 100: 46.48		CXCR2_MOUSE (18-319): 4.48e-61: 200: 18.15
+	Mm
		522397 GROA_MOUSE (31-100): 1.96e-28: 100: 44.29		CXCR2_MOUSE (18-319): 4.48e-61: 200: 18.15
+	Hs
		364080 PLF4_HUMAN (1-101): 2.41e-32: 110: 100.00		CXCR3_HUMAN (27-315): 3.94e-25: 105: 19.49
+	Mm
		291525 CXCL9_MOUSE (14-97): 1.36e-25: 93.9: 27.06		CXCR3_MOUSE (99-315): 8.88e-24: 102: 18.75
+	Mm
		291524 CXL10_MOUSE (19-98): 5.49e-23: 86.6: 28.05		CXCR3_MOUSE (99-315): 8.88e-24: 102: 18.75
+	Hs
		364105 CXL10_HUMAN (17-98): 1.58e-21: 82.8: 26.19		CXCR3_HUMAN (27-315): 3.94e-25: 105: 19.49