HitPredict

Interactor 1: CXL10 (P02778)
C-X-C motif chemokine 10 (10 kDa interferon gamma-induced protein) (Gamma-IP10) (IP-10) (Small-inducible cytokine B10) [Cleaved into: CXCL10(1-73)]
Gene: CXCL10

Interactor 2: TF65 (Q04206)
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Gene: RELA

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	18986693, 16253303, 22030901
Identification Methods	electrophoretic mobility supershift assay, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006954 - inflammatory response GO:0008284 - positive regulation of cell population proliferation GO:0016525 - negative regulation of angiogenesis GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0071222 - cellular response to lipopolysaccharide
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 98 Hs			1 551
+	Hs
		150325 CXL11_HUMAN (1-94): 7.39e-27: 95.9: 30.85		TF65_HUMAN (1-551): 0: 601: 100.00
+	Hs
		486198 IL8_HUMAN (14-92): 7.33e-23: 86.3: 23.17		TF65_HUMAN (1-551): 0: 601: 100.00
+	Hs
		587778 CXCL2_HUMAN (19-95): 1.75e-22: 85.5: 27.27		TF65_HUMAN (1-551): 0: 601: 100.00
+	Mm
		568050 CXL10_MOUSE (1-98): 6.64e-32: 108: 68.37		TF65_MOUSE (1-551): 0: 577: 87.88
+	Hs
		587791 CXCL3_HUMAN (24-94): 3.97e-21: 82: 23.94		TF65_HUMAN (1-551): 0: 601: 100.00
+	Hs
		448997 GROA_HUMAN (24-95): 7.31e-21: 81.3: 25.00		TF65_HUMAN (1-551): 0: 601: 100.00
+	Mm
		500673 CXCL2_MOUSE (17-94): 6.66e-24: 88.6: 24.36		TF65_MOUSE (1-551): 0: 577: 87.88
+	Mm
		522399 GROA_MOUSE (20-92): 1.77e-22: 85.1: 26.03		TF65_MOUSE (1-551): 0: 577: 87.88
+	Hs
		486199 IL8_HUMAN (14-92): 7.33e-23: 86.3: 23.17		REL_HUMAN (12-523): 3.56e-165: 484: 41.64
+	Hs
		364100 CXL10_HUMAN (1-98): 4.33e-29: 101: 100.00		NFKB1_HUMAN (7-451): 2.23e-153: 465: 29.51
+	Hs
		150310 CXL11_HUMAN (1-94): 7.39e-27: 95.9: 30.85		NFKB1_HUMAN (7-451): 2.23e-153: 465: 29.51
+	Hs
		486180 IL8_HUMAN (14-92): 7.33e-23: 86.3: 23.17		NFKB1_HUMAN (7-451): 2.23e-153: 465: 29.51
+	Hs
		486197 IL8_HUMAN (14-92): 7.33e-23: 86.3: 23.17		RELB_HUMAN (3-461): 2.62e-154: 455: 40.00
+	Mm
		223018 CXL13_MOUSE (25-98): 1.23e-19: 78.2: 21.62		RELB_MOUSE (13-461): 1.29e-154: 455: 38.72
+	Mm
		770720 SDF1_MOUSE (1-95): 2.24e-17: 72: 23.16		RELB_MOUSE (13-461): 1.29e-154: 455: 38.72
+	Hs
		486195 IL8_HUMAN (14-92): 7.33e-23: 86.3: 23.17		NFKB2_HUMAN (7-409): 7.21e-137: 420: 34.75