Interactor 1: TFR1 (P02786)
Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)]
Gene: TFRC
Interactor 2: HFE (Q30201)
Hereditary hemochromatosis protein (HLA-H)
Gene: HFE
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.92 | 1.00 | 0.961 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 9465039, 11027676, 14691533, 9546397, 20133674, 19254567, 15965644 |
| Identification Methods | affinity chromatography technology, pull down, surface plasmon resonance, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | C1-set~PA, MHC_I~TFR_dimer |
| Common GO terms | GO:0005615 - extracellular space GO:0005769 - early endosome GO:0005886 - plasma membrane GO:0006826 - iron ion transport GO:0006879 - intracellular iron ion homeostasis and 7 others more... |
| Homologous interactions | 4 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
