HitPredict

Interactor 1: HSP82 (P02829)
ATP-dependent molecular chaperone HSP82 (82 kDa heat shock protein) (Heat shock protein Hsp90 heat-inducible isoform)
Gene: HSP82

Interactor 2: CDC37 (P06101)
Hsp90 co-chaperone Cdc37 (Cell division control protein 37) (Hsp90 chaperone protein kinase-targeting subunit)
Gene: CDC37

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.978

The method score is based on:

Property Details
Experiments 10664467, 16554755, 24462205, 11916974, 15766533, 15879519, 15466438, 26804907, 31399574, 38705392, 20159553, 21419342, 19536198
Identification Methods affinity chromatography technology, pull down, two hybrid, tandem affinity purification, two hybrid array
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains CDC37_M~HSP90, CDC37_N~HSP90
Common GO terms GO:0005737 - cytoplasm
GO:0006457 - protein folding
GO:0050821 - protein stabilization
GO:0051082 - unfolded protein binding
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 709
Sc

1 506
+ Sc
+ Hs
+ Hs
+ Hs
+ Mm
+ Sp
+ Dm
+ Hs
+ Ce
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024