HitPredict

Interactor 1: HSP82 (P02829)
ATP-dependent molecular chaperone HSP82 (82 kDa heat shock protein) (Heat shock protein Hsp90 heat-inducible isoform)
Gene: HSP82

Interactor 2: IF4A (P10081)
ATP-dependent RNA helicase eIF4A (EC 3.6.4.13) (Eukaryotic initiation factor 4A) (eIF-4A) (Stimulator factor I 37 kDa component) (Translation initiation factor 1/2) (p37)
Gene: TIF1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	15766533, 26804907, 31399574, 37968396, 19536198
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0016887 - ATP hydrolysis activity
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 709 Sc			1 395
+	Ca
		804473 HSP90_CANAL (4-709): 0: 959: 81.75		IF4A_CANAL (2-394): 2.45e-173: 490: 78.17
+	Sc
		485627 HSC82_YEAST (1-709): 0: 973: 94.64		IF4A_YEAST (1-395): 9.95e-152: 435: 100.00
+	Sc
		365837 HSP82_YEAST (1-709): 0: 984: 100.00		DBP2_YEAST (1-392): 1.76e-131: 390: 31.42
+	Sc
		365556 HSP82_YEAST (1-709): 0: 984: 100.00		DED1_YEAST (3-395): 1.27e-125: 376: 30.19
+	Sc
		415879 HSC82_YEAST (1-709): 0: 973: 94.64		DED1_YEAST (3-395): 1.27e-125: 376: 30.19
+	Sc
		366306 HSP82_YEAST (1-709): 0: 984: 100.00		DHH1_YEAST (24-390): 2.1e-96: 298: 43.48
+	Sc
		543756 HSC82_YEAST (1-709): 0: 973: 94.64		DHH1_YEAST (24-390): 2.1e-96: 298: 43.48
+	Ca
		804529 HSP90_CANAL (4-709): 0: 959: 81.75		DHH1_CANAL (24-390): 1.19e-96: 300: 42.94
+	Tc
		1116202 Q4CQS6_TRYCC (3-709): 0: 958: 61.72		Q4DIE1_TRYCC (24-390): 1.11e-92: 285: 41.46