HitPredict

Interactor 1: HSP82 (P02829)
ATP-dependent molecular chaperone HSP82 (82 kDa heat shock protein) (Heat shock protein Hsp90 heat-inducible isoform)
Gene: HSP82

Interactor 2: STE11 (P23561)
Serine/threonine-protein kinase STE11 (EC 2.7.11.25)
Gene: STE11

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.927

Property	Details
Experiments	9802897, 14742721, 18829866, 15879519, 20159553
Identification Methods	biochemical, coimmunoprecipitation, affinity chromatography technology, pull down, two hybrid, two hybrid array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 709 Sc			1 717
+	Hs
		437928 HS90B_HUMAN (5-709): 0: 1026: 62.13		AKT2_HUMAN (293-712): 4.86e-124: 380: 18.82
+	Mm
		513660 HS90B_MOUSE (5-709): 0: 1029: 61.68		AKT1_MOUSE (293-712): 1.33e-120: 371: 18.55
+	Bt
		964601 HS90B_BOVIN (5-709): 0: 1026: 62.13		AKT1_BOVIN (293-712): 7.22e-122: 374: 18.08
+	Hs
		437927 HS90B_HUMAN (5-709): 0: 1026: 62.13		AKT1_HUMAN (293-714): 5.66e-121: 372: 18.69
+	Hs
		438469 HS90B_HUMAN (5-709): 0: 1026: 62.13		M3K3_HUMAN (171-711): 5.89e-119: 371: 26.69
+	Hs
		438633 HS90B_HUMAN (5-709): 0: 1026: 62.13		AKT3_HUMAN (295-714): 1.09e-120: 371: 18.35
+	Hs
		431573 HS90A_HUMAN (4-709): 0: 1015: 60.83		AKT2_HUMAN (293-712): 4.86e-124: 380: 18.82
+	Hs
		431572 HS90A_HUMAN (4-709): 0: 1015: 60.83		AKT1_HUMAN (293-714): 5.66e-121: 372: 18.69
+	Hs
		437900 HS90B_HUMAN (5-709): 0: 1026: 62.13		KAPCB_HUMAN (374-712): 5.07e-115: 351: 22.61
+	Hs
		431538 HS90A_HUMAN (4-709): 0: 1015: 60.83		KAPCB_HUMAN (374-712): 5.07e-115: 351: 22.61
+	Hs
		70435 HS90A_HUMAN (4-709): 0: 1015: 60.83		B2RB89_HUMAN (374-712): 5.07e-115: 351: 22.61
+	Hs
		131545 HS90B_HUMAN (5-709): 0: 1026: 62.13		STK25_HUMAN (407-715): 5.98e-101: 318: 31.39
+	Hs
		131544 HS90A_HUMAN (4-709): 0: 1015: 60.83		STK25_HUMAN (407-715): 5.98e-101: 318: 31.39
+	Hs
		438643 HS90B_HUMAN (5-709): 0: 1026: 62.13		M3K2_HUMAN (412-715): 4.71e-59: 212: 40.39
+	Hs
		438130 HS90B_HUMAN (5-709): 0: 1026: 62.13		M3K1_HUMAN (383-710): 1.59e-49: 190: 36.18
+	Hs
		312773 HS90B_HUMAN (5-709): 0: 1026: 62.13		M3K6_HUMAN (421-712): 3.24e-46: 179: 36.00
+	Hs
		431808 HS90A_HUMAN (4-709): 0: 1015: 60.83		M3K1_HUMAN (383-710): 1.59e-49: 190: 36.18
+	Hs
		438288 HS90B_HUMAN (5-709): 0: 1026: 62.13		M3K15_HUMAN (501-712): 8.75e-43: 169: 43.12
+	Hs
		312772 HS90A_HUMAN (4-709): 0: 1015: 60.83		M3K6_HUMAN (421-712): 3.24e-46: 179: 36.00
+	Hs
		431980 HS90A_HUMAN (4-709): 0: 1015: 60.83		M3K15_HUMAN (501-712): 8.75e-43: 169: 43.12