HitPredict

Interactor 1: HSP82 (P02829)
ATP-dependent molecular chaperone HSP82 (82 kDa heat shock protein) (Heat shock protein Hsp90 heat-inducible isoform)
Gene: HSP82

Interactor 2: TAH1 (P25638)
TPR repeat-containing protein associated with Hsp90
Gene: TAH1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.760

Property	Details
Experiments	24012479, 24794838, 15766533, 15879519, 18268104, 18412542, 20663878, 18268103, 19536198
Identification Methods	nuclear magnetic resonance, isothermal titration calorimetry, two hybrid, anti tag coimmunoprecipitation, x-ray crystallography, pull down, affinity chromatography technology, tandem affinity purification, two hybrid array
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000492 - box C/D snoRNP assembly GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006457 - protein folding GO:0050821 - protein stabilization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 709 Sc			1 111
+	Hs
		213454 HS90B_HUMAN (5-709): 0: 1026: 62.13		SGTA_HUMAN (2-111): 3.61e-35: 124: 28.83
+	Mm
		513680 HS90B_MOUSE (5-709): 0: 1029: 61.68		PPP5_MOUSE (1-107): 3.3e-33: 121: 20.37
+	Hs
		438021 HS90B_HUMAN (5-709): 0: 1026: 62.13		PPP5_HUMAN (1-107): 1.08e-32: 120: 20.37
+	Mm
		513709 HS90B_MOUSE (5-709): 0: 1029: 61.68		CHIP_MOUSE (2-104): 7.88e-32: 115: 27.89
+	Hs
		438621 HS90B_HUMAN (5-709): 0: 1026: 62.13		CHIP_HUMAN (2-104): 1.17e-31: 114: 27.89
+	Hs
		213451 HS90A_HUMAN (4-709): 0: 1015: 60.83		SGTA_HUMAN (2-111): 3.61e-35: 124: 28.83
+	Hs
		111935 K9JA46_HUMAN (4-709): 0: 1015: 60.83		PPP5_HUMAN (1-107): 1.08e-32: 120: 20.37
+	Hs
		431681 HS90A_HUMAN (4-709): 0: 1015: 60.83		PPP5_HUMAN (1-107): 1.08e-32: 120: 20.37
+	Mm
		432427 HS90A_MOUSE (4-709): 0: 1012: 60.72		PPP5_MOUSE (1-107): 3.3e-33: 121: 20.37
+	Hs
		438533 HS90B_HUMAN (5-709): 0: 1026: 62.13		RPAP3_HUMAN (2-107): 8.47e-27: 104: 24.30
+	At
		646594 HS901_ARATH (3-709): 0: 1001: 64.03		OE64C_ARATH (2-107): 1.49e-35: 129: 25.23
+	Hs
		432363 HS90A_HUMAN (4-709): 0: 1015: 60.83		CHIP_HUMAN (2-104): 1.17e-31: 114: 27.89
+	At
		99226 HS901_ARATH (3-709): 0: 1001: 64.03		OE64M_ARATH (1-109): 2.05e-34: 125: 22.73
+	At
		137805 HS904_ARATH (3-709): 0: 994: 61.72		OE64C_ARATH (2-107): 1.49e-35: 129: 25.23
+	Hs
		432268 HS90A_HUMAN (4-709): 0: 1015: 60.83		RPAP3_HUMAN (2-107): 8.47e-27: 104: 24.30
+	At
		99224 HS904_ARATH (3-709): 0: 994: 61.72		OE64M_ARATH (1-109): 2.05e-34: 125: 22.73
+	Hs
		437930 HS90B_HUMAN (5-709): 0: 1026: 62.13		STIP1_HUMAN (4-110): 5.68e-09: 54: 17.16
+	Hs
		111934 K9JA46_HUMAN (4-709): 0: 1015: 60.83		STIP1_HUMAN (4-110): 5.68e-09: 54: 17.16
+	Hs
		431574 HS90A_HUMAN (4-709): 0: 1015: 60.83		STIP1_HUMAN (4-110): 5.68e-09: 54: 17.16
+	Dm
		365481 HSP83_DROME (3-709): 0: 1000: 59.72		Q9VPN5_DROME (5-79): 1.21e-09: 55.8: 33.33