HitPredict

Interactor 1: HSP82 (P02829)
ATP-dependent molecular chaperone HSP82 (82 kDa heat shock protein) (Heat shock protein Hsp90 heat-inducible isoform)
Gene: HSP82

Interactor 2: CNS1 (P33313)
Hsp70/Hsp90 co-chaperone CNS1 (Cyclophilin seven suppressor 1) (STI1 stress-inducible protein homolog)
Gene: CNS1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.757

Property	Details
Experiments	9819422, 11805837, 15044454, 12788914, 15766533, 15879519, 25380751, 30876805, 19536198
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, pull down, tandem affinity purification, two hybrid array
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006457 - protein folding GO:0042026 - protein refolding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 709 Sc			1 385
+	Hs
		323394 HS90B_HUMAN (5-709): 0: 1026: 62.13		TTC4_HUMAN (33-361): 3.75e-53: 182: 22.83
+	Hs
		111932 K9JA46_HUMAN (4-709): 0: 1015: 60.83		TTC4_HUMAN (33-361): 3.75e-53: 182: 22.83
+	Hs
		323392 HS90A_HUMAN (4-709): 0: 1015: 60.83		TTC4_HUMAN (33-361): 3.75e-53: 182: 22.83
+	Mm
		513680 HS90B_MOUSE (5-709): 0: 1029: 61.68		PPP5_MOUSE (60-304): 9.4e-41: 152: 17.55
+	Hs
		438021 HS90B_HUMAN (5-709): 0: 1026: 62.13		PPP5_HUMAN (60-304): 5e-41: 153: 17.55
+	Hs
		213454 HS90B_HUMAN (5-709): 0: 1026: 62.13		SGTA_HUMAN (18-205): 3.75e-39: 143: 24.87
+	Hs
		111935 K9JA46_HUMAN (4-709): 0: 1015: 60.83		PPP5_HUMAN (60-304): 5e-41: 153: 17.55
+	Hs
		431681 HS90A_HUMAN (4-709): 0: 1015: 60.83		PPP5_HUMAN (60-304): 5e-41: 153: 17.55
+	Hs
		438524 HS90B_HUMAN (5-709): 0: 1026: 62.13		UN45A_HUMAN (84-219): 7.89e-36: 141: 27.94
+	Hs
		438089 HS90B_HUMAN (5-709): 0: 1026: 62.13		FKBP4_HUMAN (42-250): 9.43e-37: 140: 20.91
+	Hs
		438106 HS90B_HUMAN (5-709): 0: 1026: 62.13		PPID_HUMAN (19-218): 1.13e-36: 138: 21.96
+	Hs
		438336 HS90B_HUMAN (5-709): 0: 1026: 62.13		UN45B_HUMAN (83-219): 5.26e-35: 138: 29.20
+	Hs
		297025 HS90B_HUMAN (5-709): 0: 1026: 62.13		TOM70_HUMAN (81-216): 1.91e-34: 136: 27.01
+	Hs
		213451 HS90A_HUMAN (4-709): 0: 1015: 60.83		SGTA_HUMAN (18-205): 3.75e-39: 143: 24.87
+	Hs
		111936 K9JA46_HUMAN (4-709): 0: 1015: 60.83		FKBP4_HUMAN (42-250): 9.43e-37: 140: 20.91
+	Hs
		111940 K9JA46_HUMAN (4-709): 0: 1015: 60.83		UN45B_HUMAN (83-219): 5.26e-35: 138: 29.20
+	Hs
		297024 HS90A_HUMAN (4-709): 0: 1015: 60.83		TOM70_HUMAN (81-216): 1.91e-34: 136: 27.01
+	Hs
		438533 HS90B_HUMAN (5-709): 0: 1026: 62.13		RPAP3_HUMAN (34-317): 1.28e-28: 119: 17.67
+	Hs
		438464 HS90B_HUMAN (5-709): 0: 1026: 62.13		DNJC7_HUMAN (81-260): 5.77e-25: 108: 22.40
+	Hs
		438201 HS90B_HUMAN (5-709): 0: 1026: 62.13		TOM34_HUMAN (81-205): 5.31e-22: 97.2: 29.46