HitPredict

Interactor 1: HSP82 (P02829)
ATP-dependent molecular chaperone HSP82 (82 kDa heat shock protein) (Heat shock protein Hsp90 heat-inducible isoform)
Gene: HSP82

Interactor 2: AKL1 (P38080)
Serine/threonine-protein kinase AKL1 (EC 2.7.11.1)
Gene: AKL1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	26217697, 26804907, 25452130
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 709 Sc			1 1108
+	Sc
		543589 HSC82_YEAST (1-709): 0: 973: 94.64		AKL1_YEAST (1-1108): 0: 689: 100.00
+	Hs
		438138 HS90B_HUMAN (5-709): 0: 1026: 62.13		ROCK1_HUMAN (8-1107): 1.1e-129: 430: 13.52
+	Hs
		438641 HS90B_HUMAN (5-709): 0: 1026: 62.13		SIK3_HUMAN (15-1015): 1.7e-119: 401: 15.29
+	Hs
		432384 HS90A_HUMAN (4-709): 0: 1015: 60.83		SIK3_HUMAN (15-1015): 1.7e-119: 401: 15.29
+	Hs
		438521 HS90B_HUMAN (5-709): 0: 1026: 62.13		TAOK3_HUMAN (35-793): 8.14e-116: 381: 16.77
+	Hs
		438633 HS90B_HUMAN (5-709): 0: 1026: 62.13		AKT3_HUMAN (1-385): 5.68e-118: 374: 14.79
+	Hs
		432256 HS90A_HUMAN (4-709): 0: 1015: 60.83		TAOK3_HUMAN (35-793): 8.14e-116: 381: 16.77
+	Hs
		432376 HS90A_HUMAN (4-709): 0: 1015: 60.83		AKT3_HUMAN (1-385): 5.68e-118: 374: 14.79
+	Mm
		513660 HS90B_MOUSE (5-709): 0: 1029: 61.68		AKT1_MOUSE (1-373): 1.15e-112: 360: 16.54
+	Bt
		964601 HS90B_BOVIN (5-709): 0: 1026: 62.13		AKT1_BOVIN (1-373): 6.35e-113: 361: 16.80
+	Hs
		437927 HS90B_HUMAN (5-709): 0: 1026: 62.13		AKT1_HUMAN (1-373): 1.19e-112: 360: 16.54
+	Hs
		431572 HS90A_HUMAN (4-709): 0: 1015: 60.83		AKT1_HUMAN (1-373): 1.19e-112: 360: 16.54
+	Rn
		812703 HS90A_RAT (4-709): 0: 1014: 60.72		AKT1_RAT (1-373): 1.8e-112: 360: 16.54
+	Mm
		432411 HS90A_MOUSE (4-709): 0: 1012: 60.72		AKT1_MOUSE (1-373): 1.15e-112: 360: 16.54
+	Sc
		543874 HSC82_YEAST (1-709): 0: 973: 94.64		PRK1_YEAST (14-668): 3.32e-99: 334: 29.17
+	Hs
		538122 ENPL_HUMAN (3-684): 0: 904: 45.97		AKT1_HUMAN (1-373): 1.19e-112: 360: 16.54
+	Hs
		438311 HS90B_HUMAN (5-709): 0: 1026: 62.13		NEK8_HUMAN (92-314): 1.37e-16: 87: 26.81
+	Hs
		432008 HS90A_HUMAN (4-709): 0: 1015: 60.83		NEK8_HUMAN (92-314): 1.37e-16: 87: 26.81
+	Sc
		365993 HSP82_YEAST (1-709): 0: 984: 100.00		CDC5_YEAST (39-314): 1.04e-15: 84: 27.31
+	Sp
		784793 HSP90_SCHPO (3-709): 0: 945: 70.52		PLO1_SCHPO (41-316): 7.85e-17: 87.8: 28.22