HitPredict

Interactor 1: HSP82 (P02829)
ATP-dependent molecular chaperone HSP82 (82 kDa heat shock protein) (Heat shock protein Hsp90 heat-inducible isoform)
Gene: HSP82

Interactor 2: SSK2 (P53599)
MAP kinase kinase kinase SSK2 (EC 2.7.11.25) (Suppressor of sensor kinase 2)
Gene: SSK2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	15766533, 19536198
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 709 Sc			1 1579
+	Hs
		438637 HS90B_HUMAN (5-709): 0: 1026: 62.13		ST38L_HUMAN (1197-1576): 5.2e-126: 403: 20.76
+	Mm
		513660 HS90B_MOUSE (5-709): 0: 1029: 61.68		AKT1_MOUSE (1159-1577): 4.67e-123: 396: 19.54
+	Bt
		964601 HS90B_BOVIN (5-709): 0: 1026: 62.13		AKT1_BOVIN (1159-1577): 5.41e-124: 398: 19.77
+	Hs
		437928 HS90B_HUMAN (5-709): 0: 1026: 62.13		AKT2_HUMAN (1159-1577): 1.07e-123: 397: 19.30
+	Hs
		437927 HS90B_HUMAN (5-709): 0: 1026: 62.13		AKT1_HUMAN (1159-1577): 7.75e-123: 395: 18.88
+	Hs
		438188 HS90B_HUMAN (5-709): 0: 1026: 62.13		STK38_HUMAN (1196-1576): 1.22e-122: 394: 19.70
+	Hs
		432381 HS90A_HUMAN (4-709): 0: 1015: 60.83		ST38L_HUMAN (1197-1576): 5.2e-126: 403: 20.76
+	Hs
		438633 HS90B_HUMAN (5-709): 0: 1026: 62.13		AKT3_HUMAN (1171-1577): 5.07e-121: 390: 20.72
+	Hs
		438558 HS90B_HUMAN (5-709): 0: 1026: 62.13		LATS2_HUMAN (1187-1579): 5.15e-114: 389: 18.16
+	Hs
		431573 HS90A_HUMAN (4-709): 0: 1015: 60.83		AKT2_HUMAN (1159-1577): 1.07e-123: 397: 19.30
+	Hs
		431572 HS90A_HUMAN (4-709): 0: 1015: 60.83		AKT1_HUMAN (1159-1577): 7.75e-123: 395: 18.88
+	Hs
		431870 HS90A_HUMAN (4-709): 0: 1015: 60.83		STK38_HUMAN (1196-1576): 1.22e-122: 394: 19.70
+	Rn
		812703 HS90A_RAT (4-709): 0: 1014: 60.72		AKT1_RAT (1159-1577): 8.93e-123: 395: 19.54
+	Mm
		432411 HS90A_MOUSE (4-709): 0: 1012: 60.72		AKT1_MOUSE (1159-1577): 4.67e-123: 396: 19.54
+	Hs
		432376 HS90A_HUMAN (4-709): 0: 1015: 60.83		AKT3_HUMAN (1171-1577): 5.07e-121: 390: 20.72
+	Hs
		432293 HS90A_HUMAN (4-709): 0: 1015: 60.83		LATS2_HUMAN (1187-1579): 5.15e-114: 389: 18.16
+	Hs
		160340 HS90B_HUMAN (5-709): 0: 1026: 62.13		AURKA_HUMAN (1195-1579): 2.67e-94: 312: 23.88
+	Hs
		160336 HS90A_HUMAN (4-709): 0: 1015: 60.83		AURKA_HUMAN (1195-1579): 2.67e-94: 312: 23.88
+	Hs
		438469 HS90B_HUMAN (5-709): 0: 1026: 62.13		M3K3_HUMAN (1264-1553): 1.37e-38: 156: 36.49
+	Hs
		432200 HS90A_HUMAN (4-709): 0: 1015: 60.83		M3K3_HUMAN (1264-1553): 1.37e-38: 156: 36.49