HitPredict

Interactor 1: HSP82 (P02829)
ATP-dependent molecular chaperone HSP82 (82 kDa heat shock protein) (Heat shock protein Hsp90 heat-inducible isoform)
Gene: HSP82

Interactor 2: HCH1 (P53834)
Hsp90 co-chaperone HCH1 (High-copy Hsp90 suppressor protein 1)
Gene: HCH1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.952

Property	Details
Experiments	12504007, 15766533, 15633294, 31399574, 32846121, 23166640, 19536198
Identification Methods	two hybrid, affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Aha1_N~HSP90
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006457 - protein folding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 709 Sc			1 153
+	Hs
		314200 HS90B_HUMAN (5-709): 0: 1026: 62.13		AHSA1_HUMAN (5-151): 3.64e-50: 165: 26.62
+	Hs
		111931 K9JA46_HUMAN (4-709): 0: 1015: 60.83		AHSA1_HUMAN (5-151): 3.64e-50: 165: 26.62
+	Hs
		314199 HS90A_HUMAN (4-709): 0: 1015: 60.83		AHSA1_HUMAN (5-151): 3.64e-50: 165: 26.62
+	Hs
		431992 HS90A_HUMAN (4-709): 0: 1015: 60.83		AHSA2_HUMAN (5-151): 7.66e-43: 145: 20.92
+	Sc
		544183 HSC82_YEAST (1-709): 0: 973: 94.64		HCH1_YEAST (1-153): 2e-58: 180: 100.00
+	Sc
		367120 HSP82_YEAST (1-709): 0: 984: 100.00		AHA1_YEAST (1-153): 1.13e-48: 161: 36.65
+	Sc
		544634 HSC82_YEAST (1-709): 0: 973: 94.64		AHA1_YEAST (1-153): 1.13e-48: 161: 36.65
+	Sp
		784797 HSP90_SCHPO (3-709): 0: 945: 70.52		YNY8_SCHPO (4-151): 3.35e-47: 157: 32.05
+	Ce
		1090263 HSP90_CAEEL (3-709): 0: 947: 60.20		Q93168_CAEEL (5-151): 3.39e-43: 147: 26.45
+	Hs
		314218 ENPL_HUMAN (3-684): 0: 904: 45.97		AHSA1_HUMAN (5-151): 3.64e-50: 165: 26.62
+	Dm
		1360454 Q9VAY2_DROME (3-680): 0: 837: 46.67		Q9V9Q4_DROME (5-151): 2.95e-45: 153: 27.74