HitPredict

Interactor 1: HSP82 (P02829)
ATP-dependent molecular chaperone HSP82 (82 kDa heat shock protein) (Heat shock protein Hsp90 heat-inducible isoform)
Gene: HSP82

Interactor 2: SMC6 (Q12749)
Structural maintenance of chromosomes protein 6 (DNA repair protein RHC18) (Rad18 homolog)
Gene: SMC6

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	33301732, 19536198
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0016887 - ATP hydrolysis activity GO:0032204 - regulation of telomere maintenance
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 709 Sc			1 1114
+	Sc
		544661 HSC82_YEAST (1-709): 0: 973: 94.64		SMC6_YEAST (1-1114): 1.03e-104: 357: 100.00
+	Hs
		438338 HS90B_HUMAN (5-709): 0: 1026: 62.13		SMC5_HUMAN (35-1112): 5.81e-68: 250: 13.95
+	Hs
		432040 HS90A_HUMAN (4-709): 0: 1015: 60.83		SMC5_HUMAN (35-1112): 5.81e-68: 250: 13.95
+	Hs
		432296 HS90A_HUMAN (4-709): 0: 1015: 60.83		SMC4_HUMAN (5-1100): 2.66e-60: 228: 11.78
+	Sc
		366288 HSP82_YEAST (1-709): 0: 984: 100.00		SMC2_YEAST (81-1099): 9.79e-59: 223: 12.13
+	Sc
		366996 HSP82_YEAST (1-709): 0: 984: 100.00		SMC5_YEAST (70-1096): 3.83e-57: 217: 12.68
+	Hs
		437945 HS90B_HUMAN (5-709): 0: 1026: 62.13		MYH9_HUMAN (163-770): 9.14e-23: 107: 7.54
+	Hs
		431590 HS90A_HUMAN (4-709): 0: 1015: 60.83		MYH9_HUMAN (163-770): 9.14e-23: 107: 7.54
+	Hs
		431480 HS90A_HUMAN (4-709): 0: 1015: 60.83		MYH7_HUMAN (158-708): 3.02e-13: 76.6: 8.72
+	Sc
		366526 HSP82_YEAST (1-709): 0: 984: 100.00		SMC3_YEAST (247-1081): 1.13e-13: 78: 13.05
+	Sc
		544000 HSC82_YEAST (1-709): 0: 973: 94.64		SMC3_YEAST (247-1081): 1.13e-13: 78: 13.05