HitPredict - High confidence protein-protein interactions

Interactor 1: TOLC (P02930)
Outer membrane protein TolC (Multidrug efflux pump subunit TolC) (Outer membrane factor TolC)
Gene: TOLC

Interactor 2: TOLC (P02930)
Outer membrane protein TolC (Multidrug efflux pump subunit TolC) (Outer membrane factor TolC)
Gene: TOLC

Species: Escherichia coli K-12

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.893

Property	Details
Experiments	16079137, 10879525, 21245342, 25218435
Identification Methods	blue native page, x-ray crystallography, cross-linking study, molecular sieving
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	OEP~OEP
Common GO terms	GO:0005216 - monoatomic ion channel activity GO:0009279 - cell outer membrane GO:0009410 - response to xenobiotic stimulus GO:0009636 - response to toxic substance GO:0014070 - response to organic cyclic compound and 14 others more... GO:0015125 - bile acid transmembrane transporter activity GO:0015288 - porin activity GO:0015562 - efflux transmembrane transporter activity GO:0015721 - bile acid and bile salt transport GO:0016020 - membrane GO:0030288 - outer membrane-bounded periplasmic space GO:0034220 - monoatomic ion transmembrane transport GO:0042930 - enterobactin transport GO:0046677 - response to antibiotic GO:0098567 - periplasmic side of plasma membrane GO:0140330 - xenobiotic detoxification by transmembrane export across the cell outer membrane GO:1990196 - MacAB-TolC complex GO:1990281 - efflux pump complex GO:1990961 - xenobiotic detoxification by transmembrane export across the plasma membrane
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	493
Ec

1	493

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Last updated: 15 Jul 2024