Interactor 1: TOLC (P02930)
Outer membrane protein TolC (Multidrug efflux pump subunit TolC) (Outer membrane factor TolC)
Gene: TOLC

Interactor 2: ACRA (P0AE06)
Multidrug efflux pump subunit AcrA (AcrAB-TolC multidrug efflux pump subunit AcrA) (Acridine resistance protein A)
Gene: ACRA

Species: Escherichia coli K-12

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.69 1.00 0.834

The method score is based on:

Property Details
Experiments 29176613, 19805313, 15576805
Identification Methods affinity chromatography technology, surface plasmon resonance
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains CusB_dom_1~OEP, HlyD_D23~OEP
Common GO terms GO:0015721 - bile acid and bile salt transport
GO:0030288 - outer membrane-bounded periplasmic space
GO:0046677 - response to antibiotic
GO:0098567 - periplasmic side of plasma membrane
GO:0140330 - xenobiotic detoxification by transmembrane export across the cell outer membrane
and 1 others

more...

Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 493
Ec

1 397
+ Se
+ Ec
+ Ec
+ Ec

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024