Interactor 1: TOLC (P02930)
Outer membrane protein TolC (Multidrug efflux pump subunit TolC) (Outer membrane factor TolC)
Gene: TOLC

Interactor 2: MACA (P75830)
Macrolide export protein MacA
Gene: MACA

Species: Escherichia coli K-12

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.69 1.00 0.834

The method score is based on:

Property Details
Experiments 29176613, 19805313, 18955484
Identification Methods affinity chromatography technology, surface plasmon resonance, pull down
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains HlyD_D23~OEP
Common GO terms GO:0015562 - efflux transmembrane transporter activity
GO:0016020 - membrane
GO:0046677 - response to antibiotic
GO:1990196 - MacAB-TolC complex
GO:1990281 - efflux pump complex
and 1 others

more...

Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 493
Ec

1 371
+ Ec
+ Se
+ Ec
+ Ec

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Last updated: 15 Jul 2024