HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: S10A8 (P05109)
Protein S100-A8 (Calgranulin-A) (Calprotectin L1L subunit) (Cystic fibrosis antigen) (CFAG) (Leukocyte L1 complex light chain) (Migration inhibitory factor-related protein 8) (MRP-8) (p8) (S100 calcium-binding protein A8) (Urinary stone protein band A)
Gene: S100A8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	21182205, 25604459
Identification Methods	affinity chromatography technology, cosedimentation through density gradient, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008270 - zinc ion binding GO:0034121 - regulation of toll-like receptor signaling pathway
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 93
+	Hs
		369946 ESR1_HUMAN (1-595): 0: 599: 100.00		HORN_HUMAN (2-89): 7.34e-30: 112: 25.00
+	Hs
		369752 ESR1_HUMAN (1-595): 0: 599: 100.00		FILA2_HUMAN (2-89): 4.61e-25: 99.1: 29.35
+	Hs
		369283 ESR1_HUMAN (1-595): 0: 599: 100.00		S10AA_HUMAN (1-93): 5.15e-28: 98.7: 25.77
+	Hs
		685181 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		S10AB_HUMAN (2-93): 1.23e-31: 108: 26.04
+	Hs
		639034 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		S100P_HUMAN (2-92): 1.25e-30: 105: 35.79
+	Hs
		1125334 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		FILA2_HUMAN (2-89): 4.61e-25: 99.1: 29.35
+	Hs
		1269345 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		S10AG_HUMAN (3-92): 2.69e-23: 87.2: 25.26
+	Hs
		596306 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		FILA_HUMAN (2-90): 4.67e-19: 81.8: 27.96
+	Hs
		1269678 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		S10AE_HUMAN (3-80): 1.13e-20: 80.2: 20.25
+	Hs
		377001 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		S10A8_HUMAN (1-93): 2.17e-30: 104: 100.00
+	Hs
		377009 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		S10A9_HUMAN (2-88): 5.5e-28: 99.1: 26.09
+	Hs
		320221 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		S10AG_HUMAN (3-92): 2.69e-23: 87.2: 25.26
+	Hs
		320229 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		S10AE_HUMAN (3-80): 1.13e-20: 80.2: 20.25
+	Hs
		530786 RARG_HUMAN (111-574): 2.15e-103: 321: 23.52		S10A3_HUMAN (1-90): 1.52e-28: 100: 22.34
+	Hs
		487913 RARA_HUMAN (81-545): 1.35e-102: 320: 22.37		S10A3_HUMAN (1-90): 1.52e-28: 100: 22.34
+	Hs
		416373 PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35		S10A9_HUMAN (2-88): 5.5e-28: 99.1: 26.09
+	Hs
		487574 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		HORN_HUMAN (2-89): 7.34e-30: 112: 25.00