HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: ADT2 (P05141)
ADP/ATP translocase 2 (ADP,ATP carrier protein 2) (ADP,ATP carrier protein, fibroblast isoform) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5) [Cleaved into: ADP/ATP translocase 2, N-terminally processed]
Gene: SLC25A5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33731348, 21182205
Identification Methods	affinity chromatography technology, cosedimentation through density gradient
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 298
+	Hs
		368888 ESR1_HUMAN (1-595): 0: 599: 100.00		ADT3_HUMAN (1-296): 4.83e-115: 335: 92.57
+	Hs
		369817 ESR1_HUMAN (1-595): 0: 599: 100.00		SCMC1_HUMAN (98-297): 4.27e-45: 160: 23.27
+	Hs
		397461 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		ADT2_HUMAN (1-298): 6.33e-116: 337: 100.00
+	Hs
		370664 ESR1_HUMAN (1-595): 0: 599: 100.00		S2513_HUMAN (2-104): 5.95e-22: 97.6: 27.18
+	Hs
		320152 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		ADT2_HUMAN (1-298): 6.33e-116: 337: 100.00
+	Hs
		320164 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		ADT3_HUMAN (1-296): 4.83e-115: 335: 92.57
+	Hs
		518086 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		ADT1_HUMAN (1-297): 1.24e-113: 331: 89.23
+	Hs
		1156214 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SCMC1_HUMAN (98-297): 4.27e-45: 160: 23.27
+	Hs
		397226 PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14		ADT2_HUMAN (1-298): 6.33e-116: 337: 100.00
+	Hs
		1269876 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		S2513_HUMAN (2-104): 5.95e-22: 97.6: 27.18
+	Hs
		274592 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		S2512_HUMAN (2-119): 2.57e-20: 92.9: 21.01
+	Hs
		397238 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		ADT2_HUMAN (1-298): 6.33e-116: 337: 100.00
+	Hs
		487083 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		ADT3_HUMAN (1-296): 4.83e-115: 335: 92.57