Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.83 1.00 0.912

The method score is based on:

Property Details
Experiments 26348925, 28555617, 16113100, 14764897, 24051437
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Hormone_recep~fn3
Common GO terms GO:0005886 - plasma membrane
GO:0007165 - signal transduction
GO:0016020 - membrane
GO:0071392 - cellular response to estradiol stimulus
Homologous interactions 7

Homologous interactions

Color coding for hit scores

1 595
Hs

1 1367
+ Hs
+ Hs
+ Hs
+ Hs
+ Rn
+ Hs
+ Hs

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Last updated: 15 Jul 2024