HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: YBOX3 (P16989)
Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB)
Gene: YBX3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	33731348, 21182205
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008584 - male gonad development
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 372
+	Hs
		369365 ESR1_HUMAN (1-595): 0: 599: 100.00		YBOX1_HUMAN (58-372): 1.88e-52: 178: 45.89
+	Hs
		563161 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		YBOX3_HUMAN (1-372): 8.1e-79: 248: 100.00
+	Hs
		1269982 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		YBOX2_HUMAN (58-366): 4.54e-50: 173: 42.54
+	Hs
		611414 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		YBOX1_HUMAN (58-372): 1.88e-52: 178: 45.89
+	Hs
		611529 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		YBOX2_HUMAN (58-366): 4.54e-50: 173: 42.54
+	Hs
		414481 PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14		YBOX1_HUMAN (58-372): 1.88e-52: 178: 45.89