HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: ERCC3 (P19447)
General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein)
Gene: ERCC3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31527615, unassigned1953
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 782
+	Hs
		370142 ESR1_HUMAN (1-595): 0: 599: 100.00		DDX17_HUMAN (225-769): 2.71e-110: 354: 12.85
+	Hs
		368944 ESR1_HUMAN (1-595): 0: 599: 100.00		DDX5_HUMAN (198-775): 3.03e-108: 345: 12.56
+	Hs
		133828 ESR1_HUMAN (1-595): 0: 599: 100.00		DDX3X_HUMAN (204-677): 1.56e-104: 337: 11.22
+	Hs
		181675 ESR1_HUMAN (1-595): 0: 599: 100.00		DDX3Y_HUMAN (201-677): 7.95e-102: 329: 10.85
+	Hs
		370457 ESR1_HUMAN (1-595): 0: 599: 100.00		DDX31_HUMAN (204-653): 9.57e-87: 294: 13.92
+	Hs
		370546 ESR1_HUMAN (1-595): 0: 599: 100.00		DDX18_HUMAN (189-720): 1.43e-85: 287: 14.88
+	Hs
		134142 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DDX3X_HUMAN (204-677): 1.56e-104: 337: 11.22
+	Hs
		1269573 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DDX47_HUMAN (273-769): 5.98e-101: 321: 13.19
+	Hs
		1269636 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DDX31_HUMAN (204-653): 9.57e-87: 294: 13.92
+	Hs
		133914 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		DDX3X_HUMAN (204-677): 1.56e-104: 337: 11.22
+	Hs
		181691 ERR3_HUMAN (91-547): 2.27e-116: 355: 33.77		DDX3Y_HUMAN (201-677): 7.95e-102: 329: 10.85
+	Hs
		571644 NR2E1_HUMAN (171-549): 5.7e-110: 336: 29.12		DDX5_HUMAN (198-775): 3.03e-108: 345: 12.56
+	Hs
		571310 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		DDX5_HUMAN (198-775): 3.03e-108: 345: 12.56
+	Hs
		740569 PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35		DDX17_HUMAN (225-769): 2.71e-110: 354: 12.85
+	Hs
		133881 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		DDX3X_HUMAN (204-677): 1.56e-104: 337: 11.22
+	Hs
		377667 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		DDX47_HUMAN (273-769): 5.98e-101: 321: 13.19
+	Mm
		509328 RARA_MOUSE (81-545): 8.36e-104: 323: 22.37		Q8BTS0_MOUSE (198-712): 3.77e-107: 342: 12.87
+	Mm
		509320 RARA_MOUSE (81-545): 8.36e-104: 323: 22.37		DDX3X_MOUSE (243-677): 9.71e-104: 334: 11.40
+	Hs
		740610 PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35		DDX18_HUMAN (189-720): 1.43e-85: 287: 14.88
+	Hs
		133840 PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14		DDX3X_HUMAN (204-677): 1.56e-104: 337: 11.22