HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: ROA2 (P22626)
Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1)
Gene: HNRNPA2B1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	20348541, 21182205
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 353
+	Hs
		370175 ESR1_HUMAN (1-595): 0: 599: 100.00		MSI2H_HUMAN (1-341): 1.1e-55: 186: 27.57
+	Hs
		369534 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP4_HUMAN (19-200): 1.59e-38: 146: 19.67
+	Hs
		368886 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP1_HUMAN (12-200): 2.75e-37: 143: 18.95
+	Hs
		369578 ESR1_HUMAN (1-595): 0: 599: 100.00		HNRPD_HUMAN (22-191): 3.34e-37: 138: 41.77
+	Hs
		369222 ESR1_HUMAN (1-595): 0: 599: 100.00		ROA3_HUMAN (3-103): 2.78e-17: 84: 33.66
+	Hs
		368852 ESR1_HUMAN (1-595): 0: 599: 100.00		ROA1_HUMAN (3-96): 6.48e-16: 79.8: 31.92
+	Hs
		369725 ESR1_HUMAN (1-595): 0: 599: 100.00		RA1L2_HUMAN (3-96): 1.58e-15: 78.2: 31.92
+	Hs
		162100 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		HNRDL_HUMAN (12-292): 9.81e-66: 215: 33.45
+	Hs
		609976 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		ROA2_HUMAN (1-353): 9.07e-61: 200: 100.00
+	Hs
		161929 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		HNRDL_HUMAN (12-292): 9.81e-66: 215: 33.45
+	Hs
		1031409 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PABP4_HUMAN (19-200): 1.59e-38: 146: 19.67
+	Hs
		609714 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		ROA2_HUMAN (1-353): 9.07e-61: 200: 100.00
+	Mm
		579897 RARG_MOUSE (111-580): 4.46e-104: 323: 24.01		MSI2H_MOUSE (1-341): 1.5e-55: 186: 27.71
+	Hs
		782537 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		PABP4_HUMAN (19-200): 1.59e-38: 146: 19.67
+	Hs
		377317 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		HNRPD_HUMAN (22-191): 3.34e-37: 138: 41.77
+	Hs
		611434 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		PABP4_HUMAN (19-200): 1.59e-38: 146: 19.67
+	Hs
		516359 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		PABP1_HUMAN (12-200): 2.75e-37: 143: 18.95
+	Mm
		509289 RARA_MOUSE (81-545): 8.36e-104: 323: 22.37		PABP1_MOUSE (12-200): 3.28e-37: 143: 18.95
+	Hs
		377031 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		ROA1_HUMAN (3-96): 6.48e-16: 79.8: 31.92
+	Mm
		509318 RARA_MOUSE (81-545): 8.36e-104: 323: 22.37		HNRPD_MOUSE (9-100): 3.25e-17: 83.6: 30.44