HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: MCM3 (P25205)
DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)
Gene: MCM3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	23403292, 33731348
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 808
+	Hs
		627317 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MCM3_HUMAN (1-808): 0: 944: 100.00
+	Hs
		369192 ESR1_HUMAN (1-595): 0: 599: 100.00		MCM2_HUMAN (10-721): 0: 707: 30.62
+	Hs
		369081 ESR1_HUMAN (1-595): 0: 599: 100.00		MCM5_HUMAN (9-713): 0: 685: 28.92
+	Hs
		369080 ESR1_HUMAN (1-595): 0: 599: 100.00		MCM4_HUMAN (9-739): 0: 661: 28.03
+	Hs
		369082 ESR1_HUMAN (1-595): 0: 599: 100.00		MCM7_HUMAN (10-669): 0: 650: 31.62
+	Hs
		832615 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MCM2_HUMAN (10-721): 0: 707: 30.62
+	Hs
		708712 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MCM5_HUMAN (9-713): 0: 685: 28.92
+	Hs
		487140 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		MCM3_HUMAN (1-808): 0: 944: 100.00
+	Hs
		377136 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		MCM5_HUMAN (9-713): 0: 685: 28.92
+	Hs
		708820 PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35		MCM7_HUMAN (10-669): 0: 650: 31.62
+	Hs
		487232 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		MCM2_HUMAN (10-721): 0: 707: 30.62
+	Hs
		487175 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		MCM5_HUMAN (9-713): 0: 685: 28.92
+	Hs
		487176 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		MCM7_HUMAN (10-669): 0: 650: 31.62