HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: U2AF2 (P26368)
Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit)
Gene: U2AF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21182205
Identification Methods	affinity chromatography technology, cosedimentation through density gradient
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0019899 - enzyme binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 475
+	Hs
		369628 ESR1_HUMAN (1-595): 0: 599: 100.00		SART3_HUMAN (10-377): 4.33e-86: 285: 22.52
+	Hs
		369682 ESR1_HUMAN (1-595): 0: 599: 100.00		ELAV1_HUMAN (149-471): 2.84e-73: 235: 14.79
+	Hs
		369739 ESR1_HUMAN (1-595): 0: 599: 100.00		PAP1L_HUMAN (142-474): 1.36e-58: 205: 14.07
+	Hs
		369602 ESR1_HUMAN (1-595): 0: 599: 100.00		RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16
+	Hs
		369064 ESR1_HUMAN (1-595): 0: 599: 100.00		TIA1_HUMAN (253-475): 5.63e-36: 138: 15.70
+	Hs
		369421 ESR1_HUMAN (1-595): 0: 599: 100.00		TIAR_HUMAN (251-473): 6.95e-33: 130: 14.67
+	Hs
		1063262 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SART3_HUMAN (10-377): 4.33e-86: 285: 22.52
+	Hs
		369534 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP4_HUMAN (41-251): 2.07e-19: 93: 12.78
+	Hs
		368886 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP1_HUMAN (41-247): 3.26e-19: 92.6: 14.35
+	Hs
		370422 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP3_HUMAN (41-247): 1.1e-18: 91.1: 14.80
+	Hs
		1119140 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PAP1L_HUMAN (142-474): 1.36e-58: 205: 14.07
+	Hs
		1054478 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16
+	Hs
		377286 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		ELAV2_HUMAN (116-470): 6.19e-71: 230: 13.42
+	Hs
		680471 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TIA1_HUMAN (253-475): 5.63e-36: 138: 15.70
+	Hs
		963552 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TIAR_HUMAN (251-473): 6.95e-33: 130: 14.67
+	Hs
		1031409 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PABP4_HUMAN (41-251): 2.07e-19: 93: 12.78
+	Hs
		1269600 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PABP3_HUMAN (41-247): 1.1e-18: 91.1: 14.80
+	Mm
		139022 ESR2_MOUSE (22-582): 1.15e-136: 410: 45.81		RBM39_MOUSE (223-466): 2.06e-12: 71.1: 18.85
+	Hs
		782537 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		PABP4_HUMAN (41-251): 2.07e-19: 93: 12.78
+	Hs
		516359 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		PABP1_HUMAN (41-247): 3.26e-19: 92.6: 14.35