HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: PTBP1 (P26599)
Polypyrimidine tract-binding protein 1 (PTB) (57 kDa RNA-binding protein PPTB-1) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I)
Gene: PTBP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	33731348
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 557
+	Hs
		320942 ESR1_HUMAN (1-595): 0: 599: 100.00		PTBP3_HUMAN (1-557): 1.83e-101: 318: 74.01
+	Hs
		370088 ESR1_HUMAN (1-595): 0: 599: 100.00		HNRLL_HUMAN (44-556): 3.43e-96: 304: 25.91
+	Hs
		368886 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP1_HUMAN (3-375): 1.46e-44: 169: 13.58
+	Hs
		370422 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP3_HUMAN (3-375): 4.05e-44: 167: 13.42
+	Hs
		369534 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP4_HUMAN (3-378): 1.16e-43: 166: 10.62
+	Hs
		369739 ESR1_HUMAN (1-595): 0: 599: 100.00		PAP1L_HUMAN (3-380): 1.08e-42: 163: 11.86
+	Hs
		321148 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PTBP3_HUMAN (1-557): 1.83e-101: 318: 74.01
+	Hs
		1261872 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		HNRLL_HUMAN (44-556): 3.43e-96: 304: 25.91
+	Hs
		611374 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		PTBP1_HUMAN (1-557): 1.59e-120: 368: 100.00
+	Hs
		370797 ESR1_HUMAN (1-595): 0: 599: 100.00		RBM19_HUMAN (479-555): 3.4e-10: 65: 28.75
+	Hs
		1269600 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PABP3_HUMAN (3-375): 4.05e-44: 167: 13.42
+	Hs
		1031409 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PABP4_HUMAN (3-378): 1.16e-43: 166: 10.62
+	Hs
		1119140 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PAP1L_HUMAN (3-380): 1.08e-42: 163: 11.86
+	Hs
		782537 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		PABP4_HUMAN (3-378): 1.16e-43: 166: 10.62
+	Hs
		516359 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		PABP1_HUMAN (3-375): 1.46e-44: 169: 13.58
+	Hs
		446724 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SNRPA_HUMAN (361-471): 6.95e-19: 89.1: 16.38
+	Hs
		611434 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		PABP4_HUMAN (3-378): 1.16e-43: 166: 10.62
+	Mm
		509289 RARA_MOUSE (81-545): 8.36e-104: 323: 22.37		PABP1_MOUSE (3-375): 1.21e-44: 169: 13.58
+	Hs
		1270016 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		RBM19_HUMAN (479-555): 3.4e-10: 65: 28.75
+	Hs
		540897 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		HNRPL_HUMAN (15-252): 9.17e-10: 63.4: 13.31