HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: PRDX6 (P30041)
Peroxiredoxin-6 (EC 1.11.1.27) (1-Cys peroxiredoxin) (1-Cys PRX) (24 kDa protein) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.4) (Antioxidant protein 2) (Glutathione-dependent peroxiredoxin) (Liver 2D page spot 40) (Lysophosphatidylcholine acyltransferase 5) (LPC acyltransferase 5) (LPCAT-5) (Lyso-PC acyltransferase 5) (EC 2.3.1.23) (Non-selenium glutathione peroxidase) (NSGPx) (Red blood cells page spot 12)
Gene: PRDX6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23403292
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 224
+	Hs
		369073 ESR1_HUMAN (1-595): 0: 599: 100.00		PRDX2_HUMAN (2-204): 9.19e-90: 264: 28.99
+	Hs
		369052 ESR1_HUMAN (1-595): 0: 599: 100.00		PRDX3_HUMAN (6-204): 4.06e-86: 257: 25.12
+	Hs
		369520 ESR1_HUMAN (1-595): 0: 599: 100.00		PRDX4_HUMAN (3-204): 2.98e-83: 250: 24.76
+	Hs
		670745 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PRDX6_HUMAN (1-224): 7.03e-104: 301: 100.00
+	Hs
		685741 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PRDX2_HUMAN (2-204): 9.19e-90: 264: 28.99
+	Hs
		670988 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PRDX3_HUMAN (6-204): 4.06e-86: 257: 25.12
+	Hs
		1026738 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PRDX4_HUMAN (3-204): 2.98e-83: 250: 24.76
+	Hs
		670707 HNF4G_HUMAN (174-594): 3.43e-112: 343: 23.28		PRDX6_HUMAN (1-224): 7.03e-104: 301: 100.00
+	Hs
		611378 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		PRDX6_HUMAN (1-224): 7.03e-104: 301: 100.00
+	Hs
		487909 RARA_HUMAN (81-545): 1.35e-102: 320: 22.37		PRDX6_HUMAN (1-224): 7.03e-104: 301: 100.00
+	Hs
		377120 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		PRDX3_HUMAN (6-204): 4.06e-86: 257: 25.12
+	Rn
		415149 GCR_RAT (5-557): 9.7e-106: 338: 22.68		PRDX1_RAT (2-204): 2.09e-87: 258: 28.85
+	Hs
		611429 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		PRDX4_HUMAN (3-204): 2.98e-83: 250: 24.76
+	Hs
		414494 PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14		PRDX1_HUMAN (2-204): 1.79e-87: 258: 28.37
+	Hs
		487366 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		PRDX1_HUMAN (2-204): 1.79e-87: 258: 28.37
+	Hs
		487392 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		PRDX4_HUMAN (3-204): 2.98e-83: 250: 24.76