HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.725

Property	Details
Experiments	20348541, 27483141, 9222609, 15538384, 21503962, 15556606
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 840
+	Hs
		320786 ESR1_HUMAN (1-595): 0: 599: 100.00		HS74L_HUMAN (1-840): 0: 959: 63.21
+	Hs
		370116 ESR1_HUMAN (1-595): 0: 599: 100.00		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		714336 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		1267724 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		377137 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Rn
		291976 GCR_RAT (5-557): 9.7e-106: 338: 22.68		HSP74_RAT (1-840): 0: 979: 95.83
+	Hs
		611477 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		368878 ESR1_HUMAN (1-595): 0: 599: 100.00		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		369084 ESR1_HUMAN (1-595): 0: 599: 100.00		HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48
+	Hs
		368938 ESR1_HUMAN (1-595): 0: 599: 100.00		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86
+	Hs
		504498 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		714036 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48
+	Hs
		564142 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86
+	Hs
		320162 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		377052 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		504003 NR1H3_HUMAN (99-548): 6.2e-112: 343: 20.49		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		503444 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		487886 RARA_HUMAN (81-545): 1.35e-102: 320: 22.37		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		503572 PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Mm
		509285 RARA_MOUSE (81-545): 8.36e-104: 323: 22.37		HS71B_MOUSE (571-686): 9.97e-18: 89.7: 23.08