HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: SPB5 (P36952)
Serpin B5 (Maspin) (Peptidase inhibitor 5) (PI-5)
Gene: SERPINB5

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	25640309
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 375
+	Hs
		369170 ESR1_HUMAN (1-595): 0: 599: 100.00		SPB4_HUMAN (1-375): 2.63e-152: 436: 32.58
+	Hs
		668005 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SPB3_HUMAN (1-375): 2.55e-152: 436: 33.84
+	Hs
		820352 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SPB4_HUMAN (1-375): 2.63e-152: 436: 32.58
+	Hs
		344220 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		A1AT_HUMAN (2-375): 1.15e-141: 410: 25.00
+	Hs
		377126 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		ILEU_HUMAN (1-375): 1.14e-161: 459: 39.31
+	Hs
		320185 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		SPB4_HUMAN (1-375): 2.63e-152: 436: 32.58
+	Hs
		377147 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		SPB5_HUMAN (1-375): 1.75e-151: 433: 100.00
+	Hs
		344173 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		A1AT_HUMAN (2-375): 1.15e-141: 410: 25.00
+	Hs
		369205 ESR1_HUMAN (1-595): 0: 599: 100.00		SERPH_HUMAN (8-375): 2.76e-43: 157: 29.30
+	Hs
		839652 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SERPH_HUMAN (8-375): 2.76e-43: 157: 29.30
+	Hs
		377185 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		SERPH_HUMAN (8-375): 2.76e-43: 157: 29.30
+	Hs
		740471 PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35		SERPH_HUMAN (8-375): 2.76e-43: 157: 29.30