HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: GRP75 (P38646)
Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74)
Gene: HSPA9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	27483141, 21182205
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 679
+	Hs
		368878 ESR1_HUMAN (1-595): 0: 599: 100.00		HSP7C_HUMAN (51-653): 0: 883: 50.16
+	Hs
		369084 ESR1_HUMAN (1-595): 0: 599: 100.00		HS71L_HUMAN (49-673): 0: 883: 47.59
+	Hs
		368938 ESR1_HUMAN (1-595): 0: 599: 100.00		HSP76_HUMAN (49-673): 0: 875: 48.68
+	Hs
		369248 ESR1_HUMAN (1-595): 0: 599: 100.00		HSP72_HUMAN (50-653): 0: 868: 49.11
+	Hs
		504498 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		HSP7C_HUMAN (51-653): 0: 883: 50.16
+	Hs
		714036 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		HS71L_HUMAN (49-673): 0: 883: 47.59
+	Hs
		564142 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		HSP76_HUMAN (49-673): 0: 875: 48.68
+	Hs
		587131 RXRA_HUMAN (65-551): 4.55e-127: 383: 26.47		GRP75_HUMAN (1-679): 0: 873: 100.00
+	Hs
		320162 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		HSP7C_HUMAN (51-653): 0: 883: 50.16
+	Hs
		377052 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		HSP7C_HUMAN (51-653): 0: 883: 50.16
+	Hs
		320180 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		GRP75_HUMAN (1-679): 0: 873: 100.00
+	Hs
		504003 NR1H3_HUMAN (99-548): 6.2e-112: 343: 20.49		HSP7C_HUMAN (51-653): 0: 883: 50.16
+	Hs
		377151 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		GRP75_HUMAN (1-679): 0: 873: 100.00
+	Hs
		503444 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		HSP7C_HUMAN (51-653): 0: 883: 50.16
+	Hs
		611387 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		GRP75_HUMAN (1-679): 0: 873: 100.00
+	Hs
		368876 ESR1_HUMAN (1-595): 0: 599: 100.00		BIP_HUMAN (53-677): 0: 566: 50.55
+	Hs
		320161 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		BIP_HUMAN (53-677): 0: 566: 50.55
+	Hs
		377050 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		BIP_HUMAN (53-677): 0: 566: 50.55
+	Mm
		580474 ANDR_MOUSE (32-555): 1.51e-102: 332: 22.04		BIP_MOUSE (53-677): 0: 567: 51.97
+	Hs
		501682 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		BIP_HUMAN (53-677): 0: 566: 50.55