HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: SPB4 (P48594)
Serpin B4 (Leupin) (Peptidase inhibitor 11) (PI-11) (Squamous cell carcinoma antigen 2) (SCCA-2)
Gene: SERPINB4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21182205
Identification Methods	affinity chromatography technology, cosedimentation through density gradient
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019899 - enzyme binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 390
+	Hs
		369104 ESR1_HUMAN (1-595): 0: 599: 100.00		SPB5_HUMAN (1-390): 1.15e-135: 394: 33.59
+	Hs
		820352 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SPB4_HUMAN (1-390): 0: 510: 100.00
+	Hs
		668005 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SPB3_HUMAN (1-390): 9.6e-176: 496: 91.80
+	Hs
		320185 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		SPB4_HUMAN (1-390): 0: 510: 100.00
+	Hs
		344220 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		A1AT_HUMAN (2-390): 3.71e-139: 404: 32.82
+	Hs
		377126 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		ILEU_HUMAN (1-390): 1.86e-151: 434: 46.72
+	Hs
		344173 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		A1AT_HUMAN (2-390): 3.71e-139: 404: 32.82
+	Hs
		377147 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		SPB5_HUMAN (1-390): 1.15e-135: 394: 33.59