HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: TSC2 (P49815)
Tuberin (Tuberous sclerosis 2 protein)
Gene: TSC2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.653

Property	Details
Experiments	15039427, 15851513
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 1807
+	Rn
		411259 ESR1_RAT (1-595): 0: 558: 88.17		TSC2_RAT (1-1807): 0: 2744: 90.89
+	Hs
		196393 ESR1_HUMAN (1-595): 0: 599: 100.00		SI1L1_HUMAN (1451-1805): 8.9e-92: 333: 22.83
+	Hs
		230194 ESR1_HUMAN (1-595): 0: 599: 100.00		SI1L3_HUMAN (1459-1807): 3.43e-77: 286: 21.33
+	Hs
		370190 ESR1_HUMAN (1-595): 0: 599: 100.00		SIPA1_HUMAN (1258-1800): 6.13e-74: 271: 18.39
+	Hs
		1102433 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		RGPA2_HUMAN (1358-1777): 9.62e-131: 454: 21.70
+	Hs
		196487 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SI1L1_HUMAN (1451-1805): 8.9e-92: 333: 22.83
+	Hs
		1269814 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SI1L2_HUMAN (1459-1800): 2.08e-79: 293: 20.17
+	Hs
		230266 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SI1L3_HUMAN (1459-1807): 3.43e-77: 286: 21.33