HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: IF4A1 (P60842)
Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1)
Gene: EIF4A1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.680

Property	Details
Experiments	20348541, 31527615, 21182205, unassigned1953
Identification Methods	pull down, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 406
+	Hs
		368944 ESR1_HUMAN (1-595): 0: 599: 100.00		DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88
+	Hs
		370142 ESR1_HUMAN (1-595): 0: 599: 100.00		DDX17_HUMAN (2-406): 1.31e-136: 409: 29.33
+	Hs
		369113 ESR1_HUMAN (1-595): 0: 599: 100.00		IF4A3_HUMAN (1-406): 1.93e-134: 393: 66.75
+	Hs
		369014 ESR1_HUMAN (1-595): 0: 599: 100.00		DDX6_HUMAN (32-402): 1.66e-88: 278: 38.71
+	Hs
		757699 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		IF4A3_HUMAN (1-406): 1.93e-134: 393: 66.75
+	Hs
		377321 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		IF4A2_HUMAN (4-406): 4.47e-158: 453: 90.32
+	Hs
		892866 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		IF4A1_HUMAN (1-406): 1.84e-132: 387: 100.00
+	Hs
		571644 NR2E1_HUMAN (171-549): 5.7e-110: 336: 29.12		DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88
+	Hs
		571310 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88
+	Mm
		509328 RARA_MOUSE (81-545): 8.36e-104: 323: 22.37		Q8BTS0_MOUSE (10-406): 4.82e-138: 409: 29.88
+	Hs
		740569 PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35		DDX17_HUMAN (2-406): 1.31e-136: 409: 29.33
+	Hs
		640568 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DDX6_HUMAN (32-402): 1.66e-88: 278: 38.71
+	Hs
		414435 PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14		DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88
+	Hs
		414473 PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14		IF4A1_HUMAN (1-406): 1.84e-132: 387: 100.00
+	Hs
		487111 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88
+	Hs
		487641 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		DDX17_HUMAN (2-406): 1.31e-136: 409: 29.33
+	Hs
		487280 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		IF4A1_HUMAN (1-406): 1.84e-132: 387: 100.00