HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: DSG1 (Q02413)
Desmoglein-1 (Cadherin family member 4) (Desmosomal glycoprotein 1) (DG1) (DGI) (Pemphigus foliaceus antigen)
Gene: DSG1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33731348, 21182205
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 1049
+	Hs
		369580 ESR1_HUMAN (1-595): 0: 599: 100.00		DSG2_HUMAN (2-1048): 0: 742: 32.40
+	Hs
		1197750 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DSG4_HUMAN (1-1049): 0: 773: 38.52
+	Hs
		1048637 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DSG2_HUMAN (2-1048): 0: 742: 32.40
+	Hs
		377441 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		DSG4_HUMAN (1-1049): 0: 773: 38.52
+	Hs
		487989 RARA_HUMAN (81-545): 1.35e-102: 320: 22.37		DSG4_HUMAN (1-1049): 0: 773: 38.52
+	Hs
		487421 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		DSG2_HUMAN (2-1048): 0: 742: 32.40
+	Hs
		522106 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		CADH1_HUMAN (19-485): 8.8e-59: 220: 19.01
+	Hs
		1055847 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DSC3_HUMAN (1-355): 3.07e-35: 147: 20.27
+	Hs
		521768 PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35		CADH1_HUMAN (19-485): 8.8e-59: 220: 19.01