HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: FHL1 (Q13642)
Four and a half LIM domains protein 1 (FHL-1) (Skeletal muscle LIM-protein 1) (SLIM) (SLIM-1)
Gene: FHL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	22094188, 19401155
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 323
+	Hs
		369176 ESR1_HUMAN (1-595): 0: 599: 100.00		PAXI_HUMAN (37-245): 1.04e-68: 226: 28.44
+	Hs
		370434 ESR1_HUMAN (1-595): 0: 599: 100.00		ZN768_HUMAN (129-293): 9.95e-34: 131: 16.77
+	Hs
		150502 ESR1_HUMAN (1-595): 0: 599: 100.00		ABLM1_HUMAN (126-268): 7.44e-18: 86.2: 22.07
+	Hs
		369590 ESR1_HUMAN (1-595): 0: 599: 100.00		FHL2_HUMAN (3-92): 4.15e-15: 76.2: 34.78
+	Hs
		368935 ESR1_HUMAN (1-595): 0: 599: 100.00		ZN182_HUMAN (215-318): 2.58e-13: 72.5: 13.46
+	Hs
		823459 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PAXI_HUMAN (37-245): 1.04e-68: 226: 28.44
+	Hs
		377645 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		ZN251_HUMAN (22-317): 8.15e-88: 278: 11.96
+	Hs
		377370 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		ZN568_HUMAN (2-213): 4.02e-82: 262: 15.42
+	Hs
		200153 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		TGFI1_HUMAN (37-246): 3.97e-61: 203: 29.25
+	Hs
		1269616 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		ZN768_HUMAN (129-293): 9.95e-34: 131: 16.77
+	Hs
		150608 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		ABLM1_HUMAN (126-268): 7.44e-18: 86.2: 22.07
+	Hs
		782683 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		ZN629_HUMAN (2-210): 8.61e-19: 89.1: 7.35
+	Hs
		238944 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		LPXN_HUMAN (3-98): 1.47e-22: 98.5: 22.92
+	Hs
		1055261 HNF4G_HUMAN (174-594): 3.43e-112: 343: 23.28		ZN629_HUMAN (2-210): 8.61e-19: 89.1: 7.35
+	Hs
		377601 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		PRIC1_HUMAN (119-228): 8.54e-10: 61.6: 26.13
+	Mm
		579891 RARG_MOUSE (111-580): 4.46e-104: 323: 24.01		PRIC1_MOUSE (119-228): 9.1e-10: 61.6: 26.13
+	Hs
		200156 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		TGFI1_HUMAN (37-246): 3.97e-61: 203: 29.25
+	Hs
		487425 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		FHL2_HUMAN (3-92): 4.15e-15: 76.2: 34.78