HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: FKBP8 (Q14318)
Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase)
Gene: FKBP8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31527615, unassigned1953
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005516 - calmodulin binding GO:0005829 - cytosol GO:0016020 - membrane GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 412
+	Hs
		369479 ESR1_HUMAN (1-595): 0: 599: 100.00		PPID_HUMAN (5-369): 4.48e-66: 216: 18.06
+	Hs
		370658 ESR1_HUMAN (1-595): 0: 599: 100.00		FKBPL_HUMAN (8-369): 7.94e-52: 178: 22.43
+	Hs
		1053109 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		FKBP8_HUMAN (1-412): 5.79e-102: 310: 100.00
+	Hs
		369442 ESR1_HUMAN (1-595): 0: 599: 100.00		FKBP4_HUMAN (72-404): 6.45e-24: 105: 18.18
+	Hs
		369072 ESR1_HUMAN (1-595): 0: 599: 100.00		STIP1_HUMAN (218-357): 3.76e-20: 94.2: 20.00
+	Hs
		369544 ESR1_HUMAN (1-595): 0: 599: 100.00		FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21
+	Hs
		377276 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		PPID_HUMAN (5-369): 4.48e-66: 216: 18.06
+	Hs
		437638 MCR_HUMAN (21-554): 3.98e-103: 335: 22.01		PPID_HUMAN (5-369): 4.48e-66: 216: 18.06
+	Hs
		1025273 NR1H3_HUMAN (99-548): 6.2e-112: 343: 20.49		FKBPL_HUMAN (8-369): 7.94e-52: 178: 22.43
+	Hs
		118677 MCR_HUMAN (21-554): 3.98e-103: 335: 22.01		AIP_HUMAN (97-369): 4.45e-54: 184: 18.94
+	Hs
		377261 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		FKBP4_HUMAN (72-404): 6.45e-24: 105: 18.18
+	Mm
		415156 GCR_MOUSE (5-557): 4.61e-107: 341: 21.82		FKBP4_MOUSE (72-404): 2.2e-24: 106: 18.86
+	Hs
		377132 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		STIP1_HUMAN (218-357): 3.76e-20: 94.2: 20.00
+	Hs
		437634 MCR_HUMAN (21-554): 3.98e-103: 335: 22.01		FKBP4_HUMAN (72-404): 6.45e-24: 105: 18.18
+	Hs
		377301 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21
+	Mm
		415159 GCR_MOUSE (5-557): 4.61e-107: 341: 21.82		FKBP5_MOUSE (81-405): 2.57e-19: 91.5: 16.89
+	Hs
		1025252 NR1H3_HUMAN (99-548): 6.2e-112: 343: 20.49		FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21
+	Hs
		437640 MCR_HUMAN (21-554): 3.98e-103: 335: 22.01		FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21
+	Hs
		414489 PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14		FKBP4_HUMAN (72-404): 6.45e-24: 105: 18.18
+	Hs
		414449 PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14		STIP1_HUMAN (218-357): 3.76e-20: 94.2: 20.00