HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: SMC1A (Q14683)
Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8)
Gene: SMC1A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	20348541
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 1233
+	Hs
		311456 ESR1_HUMAN (1-595): 0: 599: 100.00		SMC2_HUMAN (3-1214): 1.55e-77: 281: 17.57
+	Hs
		370526 ESR1_HUMAN (1-595): 0: 599: 100.00		SMC4_HUMAN (4-1216): 2.64e-76: 278: 19.90
+	Hs
		370733 ESR1_HUMAN (1-595): 0: 599: 100.00		SMC3_HUMAN (3-1229): 1.52e-70: 260: 16.00
+	Hs
		1057341 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SMC1A_HUMAN (1-1233): 1.94e-128: 427: 100.00
+	Hs
		377326 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		SMC1A_HUMAN (1-1233): 1.94e-128: 427: 100.00
+	Hs
		369096 ESR1_HUMAN (1-595): 0: 599: 100.00		MYH9_HUMAN (49-760): 1.43e-25: 117: 11.62
+	Hs
		311597 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SMC2_HUMAN (3-1214): 1.55e-77: 281: 17.57
+	Hs
		1269723 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SMC4_HUMAN (4-1216): 2.64e-76: 278: 19.90
+	Hs
		368902 ESR1_HUMAN (1-595): 0: 599: 100.00		MYH6_HUMAN (51-434): 4.09e-11: 70.1: 13.14
+	Hs
		1269952 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SMC3_HUMAN (3-1229): 1.52e-70: 260: 16.00
+	Hs
		782697 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		SMC3_HUMAN (3-1229): 1.52e-70: 260: 16.00
+	Hs
		487432 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		SMC1A_HUMAN (1-1233): 1.94e-128: 427: 100.00
+	Hs
		724944 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MYH9_HUMAN (49-760): 1.43e-25: 117: 11.62
+	Hs
		587127 RXRA_HUMAN (65-551): 4.55e-127: 383: 26.47		MYH9_HUMAN (49-760): 1.43e-25: 117: 11.62
+	Hs
		1270044 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MYH4_HUMAN (659-1132): 9.83e-17: 88.2: 10.58
+	Hs
		522631 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MYH7_HUMAN (51-420): 1.04e-10: 68.6: 13.37
+	Hs
		377795 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		MYH2_HUMAN (495-1125): 5.14e-20: 99: 9.49
+	Hs
		487850 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		SMC3_HUMAN (3-1229): 1.52e-70: 260: 16.00