HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: UBE3C (Q15386)
Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL)
Gene: UBE3C

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	26389696
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 1083
+	Hs
		369460 ESR1_HUMAN (1-595): 0: 599: 100.00		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		370480 ESR1_HUMAN (1-595): 0: 599: 100.00		SMUF1_HUMAN (562-1080): 3.14e-177: 539: 22.78
+	Hs
		983200 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		1269572 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		WWP1_HUMAN (599-1081): 1.77e-174: 537: 25.66
+	Hs
		377267 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		437637 MCR_HUMAN (21-554): 3.98e-103: 335: 22.01		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		377607 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		NED4L_HUMAN (572-1081): 2.17e-174: 538: 25.33
+	Hs
		487952 RARA_HUMAN (81-545): 1.35e-102: 320: 22.37		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		1336130 NR2E1_HUMAN (171-549): 5.7e-110: 336: 29.12		SMUF1_HUMAN (562-1080): 3.14e-177: 539: 22.78
+	Hs
		740458 PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35		NEDD4_HUMAN (291-1081): 4.42e-178: 558: 20.10
+	Hs
		611504 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		SMUF2_HUMAN (557-1080): 7.6e-179: 542: 22.77
+	Hs
		369911 ESR1_HUMAN (1-595): 0: 599: 100.00		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Hs
		414493 PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		983199 NR4A3_HUMAN (185-534): 1.48e-37: 149: 30.70		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		487361 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		1192145 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Hs
		500370 RARB_HUMAN (111-579): 7.62e-114: 349: 22.47		HACE1_HUMAN (694-1078): 3.71e-47: 185: 31.50
+	Hs
		530804 RARG_HUMAN (111-574): 2.15e-103: 321: 23.52		HACE1_HUMAN (694-1078): 3.71e-47: 185: 31.50
+	Hs
		487995 RARA_HUMAN (81-545): 1.35e-102: 320: 22.37		HACE1_HUMAN (694-1078): 3.71e-47: 185: 31.50
+	Hs
		487557 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60