HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: DREB (Q16643)
Drebrin (Developmentally-regulated brain protein)
Gene: DBN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	20348541, 21182205
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 649
+	Hs
		370665 ESR1_HUMAN (1-595): 0: 599: 100.00		DBNL_HUMAN (3-464): 1.68e-73: 244: 29.98
+	Hs
		369815 ESR1_HUMAN (1-595): 0: 599: 100.00		NIPBL_HUMAN (124-505): 2.57e-30: 130: 11.06
+	Hs
		369994 ESR1_HUMAN (1-595): 0: 599: 100.00		MINK1_HUMAN (185-545): 2.22e-27: 120: 13.66
+	Hs
		1085019 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DREB_HUMAN (1-649): 5.59e-95: 307: 100.00
+	Hs
		370105 ESR1_HUMAN (1-595): 0: 599: 100.00		TITIN_HUMAN (148-594): 2.68e-10: 66.3: 11.55
+	Hs
		1269877 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DBNL_HUMAN (3-464): 1.68e-73: 244: 29.98
+	Hs
		1187996 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TICRR_HUMAN (172-580): 4.23e-35: 144: 12.95
+	Hs
		1154059 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		NIPBL_HUMAN (124-505): 2.57e-30: 130: 11.06
+	Hs
		1233527 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MINK1_HUMAN (185-545): 2.22e-27: 120: 13.66
+	Hs
		1221286 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		RB12B_HUMAN (173-626): 1.39e-17: 89.1: 13.95
+	Hs
		782571 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		NIPBL_HUMAN (124-505): 2.57e-30: 130: 11.06
+	Hs
		517813 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		NFH_HUMAN (248-646): 2.23e-15: 82.2: 11.72
+	Hs
		377401 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		NIPBL_HUMAN (124-505): 2.57e-30: 130: 11.06
+	Hs
		1264774 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TITIN_HUMAN (148-594): 2.68e-10: 66.3: 11.55
+	Hs
		1270066 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PCLO_HUMAN (135-639): 1.66e-09: 63.7: 9.64
+	Hs
		1186078 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MICA3_HUMAN (205-642): 2.69e-09: 62.9: 11.11
+	Hs
		377539 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		TITIN_HUMAN (148-594): 2.68e-10: 66.3: 11.55
+	Mm
		1142660 ERR2_MOUSE (92-547): 6.98e-113: 345: 34.42		KMT2D_MOUSE (165-637): 7.73e-09: 61.4: 11.07
+	Hs
		487522 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		NIPBL_HUMAN (124-505): 2.57e-30: 130: 11.06