HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: WIPI1 (Q5MNZ9)
WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1) (Atg18 protein homolog) (WD40 repeat protein interacting with phosphoinositides of 49 kDa) (WIPI 49 kDa)
Gene: WIPI1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	15602573
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030331 - nuclear estrogen receptor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 446
+	Hs
		369648 ESR1_HUMAN (1-595): 0: 599: 100.00		PWP2_HUMAN (14-326): 2.69e-47: 176: 14.15
+	Hs
		370069 ESR1_HUMAN (1-595): 0: 599: 100.00		UTP15_HUMAN (19-330): 7.69e-49: 176: 16.42
+	Hs
		369305 ESR1_HUMAN (1-595): 0: 599: 100.00		WDR5_HUMAN (1-214): 1.32e-46: 165: 8.60
+	Hs
		370377 ESR1_HUMAN (1-595): 0: 599: 100.00		TBL1R_HUMAN (137-357): 5.09e-33: 132: 10.92
+	Hs
		369669 ESR1_HUMAN (1-595): 0: 599: 100.00		TAF5_HUMAN (134-409): 8.11e-31: 127: 11.11
+	Hs
		196938 ESR1_HUMAN (1-595): 0: 599: 100.00		PRP4_HUMAN (128-347): 9.32e-30: 123: 13.42
+	Hs
		370309 ESR1_HUMAN (1-595): 0: 599: 100.00		TBL1Y_HUMAN (1-126): 1.33e-22: 102: 10.79
+	Hs
		370470 ESR1_HUMAN (1-595): 0: 599: 100.00		GBB4_HUMAN (158-359): 2.99e-23: 101: 10.63
+	Hs
		267731 ESR1_HUMAN (1-595): 0: 599: 100.00		TAF5L_HUMAN (175-348): 2.98e-15: 80.1: 11.17
+	Hs
		369932 ESR1_HUMAN (1-595): 0: 599: 100.00		WDR5B_HUMAN (267-442): 4.97e-14: 74.9: 11.00
+	Hs
		370394 ESR1_HUMAN (1-595): 0: 599: 100.00		SKI8_HUMAN (4-172): 1.99e-09: 60.6: 15.28
+	Hs
		1070019 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PWP2_HUMAN (14-326): 2.69e-47: 176: 14.15
+	Hs
		1256110 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		UTP15_HUMAN (19-330): 7.69e-49: 176: 16.42
+	Hs
		903403 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		WDR5_HUMAN (1-214): 1.32e-46: 165: 8.60
+	Hs
		1269548 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TBL1R_HUMAN (137-357): 5.09e-33: 132: 10.92
+	Hs
		1074801 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TAF5_HUMAN (134-409): 8.11e-31: 127: 11.11
+	Hs
		197064 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PRP4_HUMAN (128-347): 9.32e-30: 123: 13.42
+	Hs
		1269467 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TBL1Y_HUMAN (1-126): 1.33e-22: 102: 10.79
+	Hs
		267782 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TAF5L_HUMAN (175-348): 2.98e-15: 80.1: 11.17
+	Hs
		1269559 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SKI8_HUMAN (4-172): 1.99e-09: 60.6: 15.28