HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: SRRM1 (Q8IYB3)
Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein)
Gene: SRRM1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21182205
Identification Methods	affinity chromatography technology, cosedimentation through density gradient
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 904
+	Hs
		257541 ESR1_HUMAN (1-595): 0: 599: 100.00		ANR17_HUMAN (107-903): 3.38e-30: 131: 13.10
+	Hs
		370607 ESR1_HUMAN (1-595): 0: 599: 100.00		CHD7_HUMAN (120-837): 5.02e-29: 127: 10.84
+	Hs
		369728 ESR1_HUMAN (1-595): 0: 599: 100.00		MA7D1_HUMAN (112-867): 3.1e-27: 121: 9.91
+	Hs
		370417 ESR1_HUMAN (1-595): 0: 599: 100.00		TARA_HUMAN (120-893): 4.39e-14: 79.2: 11.35
+	Hs
		369607 ESR1_HUMAN (1-595): 0: 599: 100.00		MDC1_HUMAN (204-903): 7.29e-13: 75: 9.61
+	Hs
		370092 ESR1_HUMAN (1-595): 0: 599: 100.00		ATX2L_HUMAN (104-788): 2.79e-11: 69.6: 10.35
+	Hs
		368927 ESR1_HUMAN (1-595): 0: 599: 100.00		MUC1_HUMAN (164-720): 6.29e-11: 68.6: 15.61
+	Hs
		369815 ESR1_HUMAN (1-595): 0: 599: 100.00		NIPBL_HUMAN (207-894): 1.06e-10: 68.2: 13.58
+	Hs
		369869 ESR1_HUMAN (1-595): 0: 599: 100.00		CRACD_HUMAN (103-899): 3.33e-10: 66.1: 11.04
+	Hs
		370040 ESR1_HUMAN (1-595): 0: 599: 100.00		KMT2C_HUMAN (390-904): 1.47e-09: 64.6: 11.65
+	Hs
		370800 ESR1_HUMAN (1-595): 0: 599: 100.00		C170B_HUMAN (129-899): 3.7e-09: 63: 10.66
+	Hs
		370728 ESR1_HUMAN (1-595): 0: 599: 100.00		SRRM2_HUMAN (189-896): 4.93e-09: 62.6: 13.28
+	Hs
		152573 ESR1_HUMAN (1-595): 0: 599: 100.00		KMT2D_HUMAN (365-903): 9.97e-09: 61.9: 12.32
+	Hs
		257677 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		ANR17_HUMAN (107-903): 3.38e-30: 131: 13.10
+	Hs
		1056909 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MDC1_HUMAN (204-903): 7.29e-13: 75: 9.61
+	Hs
		517813 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		NFH_HUMAN (481-904): 1.02e-11: 70.9: 14.55
+	Hs
		554348 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MUC1_HUMAN (164-720): 6.29e-11: 68.6: 15.61
+	Hs
		1154059 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		NIPBL_HUMAN (207-894): 1.06e-10: 68.2: 13.58
+	Hs
		1016138 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		ARHG5_HUMAN (95-798): 1.79e-09: 63.8: 12.24
+	Hs
		152674 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		KMT2D_HUMAN (365-903): 9.97e-09: 61.9: 12.32